| Predicted mutation | |||||||
|---|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | freq | annotation | gene | description |
| RA | NC_000913 | 1,982,585 | C→A | 6.8% | R319L (CGT→CTT) | araH ← | L‑arabinose ABC transporter permease |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_000913 | 1,982,585 | 0 | C | A | 6.8% | 193.0 / 3.5 | 59 | R319L (CGT→CTT) | araH | L‑arabinose ABC transporter permease |
| Reads supporting (aligned to +/- strand): ref base C (25/30); new base A (2/2); total (27/32) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 1.00e+00 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 8.78e-01 | |||||||||||
GACATGTAAGTATAGACAGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCGCCACCACATATGAGATTTTTCCGATGCCACCTTT > NC_000913/1982440‑1982733 | gagaTGTAAGTATTGACAGTGTGACGGGGGGCGGCATTTGCAACGAAGAACAGCCAACGGTTATGGCGGTTGGCTATGGTGGGAAAAAAGGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGt < 6:104887/146‑1 (MQ=255) cATGTAAGTATAGACAGTGTGACGGGGGTCGCCATTTGCAACGTAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAATTTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCg < 8:275742/149‑1 (MQ=255) gTAAGTATAGACAGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCGAAATTGTTGCAG‑CAAAAAGCATCAGCCAGTGCGTTTCGCTTTTTGCTTGTAACGGGCg > 4:219899/1‑146 (MQ=255) tAAGTATAGACAGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCg > 7:189156/1‑145 (MQ=255) tataGACAGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCAc < 1:248137/149‑1 (MQ=255) taGACAGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCAcc < 7:38908/148‑1 (MQ=255) taGACAGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCg > 7:278764/1‑149 (MQ=255) aGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGc > 3:306583/1‑148 (MQ=255) gtgtGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGc > 8:66822/1‑147 (MQ=255) aCGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCcagcag > 7:220518/1‑148 (MQ=255) gggggTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGAt < 7:113745/149‑1 (MQ=255) gggggTCGCCATTTGAAAATAAAAAAAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAGAAACGCGATATTGGTGCAG‑CAAACAGCATCGGCCGGTGCGTTTGGCTGTTTGCTTGTATCGGTCGCAGATCAGCGCTGCCAGCAGGAt > 6:182321/1‑149 (MQ=255) gggTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGAtt > 4:186016/1‑148 (MQ=255) gCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTa > 7:48196/1‑144 (MQ=255) gCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTa < 8:48196/144‑1 (MQ=255) gCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCcagca > 6:11252/1‑131 (MQ=255) gCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCcagca < 5:11252/131‑1 (MQ=255) cAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGGGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGAGTCAGCCGCGAACCAc > 6:77462/1‑149 (MQ=255) aaCGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCcagc < 7:62177/128‑1 (MQ=255) aaCGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCcagc > 8:62177/1‑128 (MQ=255) aaCGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACg > 2:41775/1‑149 (MQ=255) ccAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGTCGCGAACCACGTACTGCGCGaaa < 1:284796/149‑1 (MQ=255) ccAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGaaa < 5:131290/149‑1 (MQ=255) cAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAg < 3:186016/149‑1 (MQ=255) aaCCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAg > 2:304951/1‑148 (MQ=255) aaCCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAg > 3:250542/1‑148 (MQ=255) ttATGGCGGGTGGCTATGGTGGGAAAAAACGCGAATTTGTTGCAG‑AAAAAAGCTTCAGACAGTGCGTTTCGCTTTTTCCTTGTAACGGACGAAGATAACCCCTACCACAAGGATTAAGCCGCGAACAACGAACTGCGCGAAAgaagaa > 1:239647/1‑148 (MQ=255) gCGGTTGGCTATTGTGGGAAAAAACGCTAAATTGTTGCAGAAAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATAtt < 4:238955/149‑1 (MQ=255) ggCTATGGTTGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTTAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAg < 6:277774/148‑1 (MQ=255) tATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGtt > 6:116976/1‑148 (MQ=255) tATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAAAGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGtt > 2:27493/1‑148 (MQ=255) tATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAAAGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGtt > 4:287921/1‑148 (MQ=255) tggtggGAAAATACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACGACGTACTGCGGGAAAGGAGAAATATTAAGCAGGTTCa < 2:239647/148‑1 (MQ=255) gtggGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATg < 8:220518/148‑1 (MQ=255) ggAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGt > 7:8438/1‑149 (MQ=255) aaaaaaCGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGttt > 5:51514/1‑149 (MQ=255) aaaaaaCGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACATACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGttt < 4:306583/149‑1 (MQ=255) aaaaCGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTc < 4:16675/149‑1 (MQ=255) aaaaCGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTc < 6:200418/149‑1 (MQ=255) aaCGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCTCCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCa < 1:6894/149‑1 (MQ=255) gCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACgg > 1:140042/1‑149 (MQ=255) aaTTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGc < 8:278764/148‑1 (MQ=255) gCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAAt > 7:256193/1‑148 (MQ=255) cAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAAtt > 6:281450/1‑148 (MQ=255) aG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAAtt > 6:110300/1‑147 (MQ=255) aG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTaa < 3:219899/149‑1 (MQ=255) aG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTaa < 2:140042/149‑1 (MQ=255) aG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAAAGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTaa < 3:287921/149‑1 (MQ=255) aG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAAAGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTaa < 1:27493/149‑1 (MQ=255) g‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAg < 6:51514/149‑1 (MQ=255) aaaaGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATa < 5:182321/149‑1 (MQ=255) aGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATAccc < 8:270760/149‑1 (MQ=255) gACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCGccacca < 1:41775/149‑1 (MQ=255) gACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTGCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCGccacca < 4:250542/149‑1 (MQ=255) aGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAg > 4:189971/1‑99 (MQ=255) aGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAg < 3:189971/99‑1 (MQ=255) tGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCGccac < 4:269634/142‑1 (MQ=255) tGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCGccac > 3:269634/1‑142 (MQ=255) tttGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCGCCACCACATATGAGATTTTTc < 7:66822/147‑1 (MQ=255) cGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCTCCACCACATATGAGATTTTTCCGATGCCACCttt < 1:304951/149‑1 (MQ=255) | GACATGTAAGTATAGACAGTGTGACGGGGGTCGCCATTTGCAACGAAGAACAGCCAACCGTTATGGCGGTTGGCTATGGTGGGAAAAAACGCTAAATTGTTGCAG‑AAAAAAGCATCAGACAGTGCGTTTCGCTTTTTGCTTGTAACGGTCGAAGATCACCGCTGCCAGCAGGATTAAGCCGCGAACCACGTACTGCGCGAAAGGAGAAATATTAAGCAGGTTCATGGCGTTTTCCACGGTGCCTAAAATTAAGATACCCGCCACCACATATGAGATTTTTCCGATGCCACCTTT > NC_000913/1982440‑1982733 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 14 ≤ ATCG/ATCG < 21 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 36 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |