Predicted mutation | |||||||
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evidence | seq id | position | mutation | freq | annotation | gene | description |
RA | NC_000913 | 1,273,229 | A→T | 15.3% | intergenic (+27/+17) | chaC → / ← ychN | cation transport regulator/putative sulfur relay protein |
Read alignment evidence... | |||||||||||
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seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
* | NC_000913 | 1,273,229 | 0 | A | T | 15.3% | 217.0 / 32.9 | 85 | intergenic (+27/+17) | chaC/ychN | cation transport regulator/putative sulfur relay protein |
Reads supporting (aligned to +/- strand): ref base A (39/33); new base T (3/10); total (42/43) | |||||||||||
Fisher's exact test for biased strand distribution p-value = 6.79e-02 | |||||||||||
Kolmogorov-Smirnov test that lower quality scores support variant p-value = 1.83e-01 |
TTTGCTGGTATCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCATCAATCAG > NC_000913/1273130‑1273326 | tttGCTGGTATCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCa > 1:149085/1‑100 (MQ=255) tGCTGGTATCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTCAACTTCCCGCATAGTGGGGCGTCAGa > 1:56521/1‑100 (MQ=255) tGCTGGTATCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGa < 1:1127179/100‑1 (MQ=255) gtGGTATCGTTAAGAAAACTGCTGGCGGAGAATTTTGCGGATGGTGTGTGACGGCCGGGATTCGCCTGAGTAAACTTTCGGCATAGTGGGGCTGCAGACg > 2:228786/2‑100 (MQ=255) tATCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGcccc > 1:1354763/1‑100 (MQ=255) aTCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGccccc < 1:44214/100‑1 (MQ=255) tCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccac < 1:1813574/100‑3 (MQ=255) tCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccac < 1:1154476/100‑3 (MQ=255) tCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccac < 2:956974/100‑3 (MQ=255) cGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccact < 2:1776823/100‑4 (MQ=255) cGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTc > 1:552186/1‑100 (MQ=255) cGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTc > 1:1190023/1‑100 (MQ=255) ggTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCa > 1:372190/1‑100 (MQ=255) gTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccactat < 2:1766371/100‑6 (MQ=255) tAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCaaa > 1:1402399/1‑100 (MQ=255) tAAAAAAACTGCTGGCGGAGAAGTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccactatg < 1:2100328/100‑7 (MQ=255) aaaaaaaCTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccactatgc < 1:980601/100‑8 (MQ=255) aaaaaCTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccactatgcgg < 1:1377454/100‑10 (MQ=39) aaaaaCTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccactatgcgg < 1:1027936/100‑10 (MQ=39) aaaaaCTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACAt < 2:2137542/100‑1 (MQ=255) aaaaCTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCTGACGccccactatgcggg < 2:539820/100‑11 (MQ=38) aCTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTaaa < 2:898983/100‑1 (MQ=255) ctgctgGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTAGGGCGTCAGACGCCCCCTCAAACATTaaaa > 1:1184856/1‑100 (MQ=255) ggCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGa < 1:766537/100‑1 (MQ=255) gCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAg < 2:342144/100‑1 (MQ=255) gCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAg < 2:358625/100‑1 (MQ=255) cGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGc > 1:1415177/1‑100 (MQ=255) ccgatctttCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCAc < 1:759290/94‑1 (MQ=255) aTTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTa > 1:1799281/1‑100 (MQ=255) aTTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTa < 1:1391071/100‑1 (MQ=255) aTTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTa > 2:246886/1‑100 (MQ=255) aTTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGAGTCAGAAGCCCCCTCAAACATTAAAATGTGAGCACTTTa > 2:653481/1‑100 (MQ=255) ttttCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTAt < 2:1579437/100‑1 (MQ=255) tttCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATc > 2:1374610/1‑100 (MQ=255) ttCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCAcagatcgg > 2:759288/1‑93 (MQ=255) ttCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCg > 2:895219/1‑100 (MQ=255) ccGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGc < 2:552184/100‑1 (MQ=255) ccGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGc < 1:1374618/100‑1 (MQ=255) cGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCt > 2:931382/1‑100 (MQ=255) cGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCt > 1:1596344/1‑100 (MQ=255) ggATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTg < 1:1085094/100‑1 (MQ=255) ggATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTg < 1:1132409/100‑1 (MQ=255) ggATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTg < 2:329068/100‑1 (MQ=255) aTGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGAc < 1:1524551/100‑1 (MQ=255) aTGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGAc < 2:613078/100‑1 (MQ=255) tGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACa < 1:993443/100‑1 (MQ=255) gtgtgtTACGTACGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGCGAGCACTTTATCGGCTGACAGc > 2:1830944/1‑100 (MQ=255) tgtTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTc > 1:963307/1‑100 (MQ=255) gtTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTcc > 2:842549/1‑100 (MQ=255) gtTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTcc > 2:1745085/1‑100 (MQ=255) gtTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTcc > 1:930089/1‑100 (MQ=255) gtTACGTCCGGGAGTCGCCTGAGTAAACTGCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTcc < 2:2004321/100‑1 (MQ=255) ttACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGAGTCAGAAGCCCCCTCAAACATTAAAATGTGGGCACTTTATCGGCTGACAGCGTCCa > 2:1520155/1‑100 (MQ=255) tCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTgcg > 1:2217854/1‑100 (MQ=255) ccGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTgcgc < 2:762094/100‑1 (MQ=255) ccGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTgcgc < 2:93642/100‑1 (MQ=255) cGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTgcg < 2:182956/98‑1 (MQ=255) gggATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCa > 2:1329042/1‑100 (MQ=255) ttCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTc > 1:2053611/1‑100 (MQ=255) tCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTcc < 1:2263594/100‑1 (MQ=255) cGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCca > 1:1141611/1‑100 (MQ=255) gCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCcac < 2:1549178/100‑1 (MQ=255) gAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAaga > 1:2273557/1‑100 (MQ=255) aaaCTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCGGTTCCACAAGAGTAc > 1:2354905/1‑100 (MQ=255) aaaCTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTAc > 1:811172/1‑100 (MQ=255) aaaCTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTAc > 2:574746/1‑100 (MQ=255) cTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCCCAAGAGTACCGa > 1:1262956/1‑100 (MQ=255) cTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGa > 2:207222/1‑100 (MQ=255) cTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGa > 2:323183/1‑100 (MQ=255) tCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGAtt < 1:2082123/100‑1 (MQ=255) cccGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACGAGAGTACCGAttt > 2:2104455/1‑100 (MQ=255) cctcagaGTGGCGCGTCAGTAGTCCCCTCAATCACTAAACTCTGAACACTTTATCGGCTGTCAGCGTCCTTTTCGCCAGTTCCACAAGAGTACCGAttt < 2:1732470/93‑1 (MQ=255) ccGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTc > 1:664485/1‑100 (MQ=255) cGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTcc > 1:2050541/1‑100 (MQ=255) ttgagggggCGTCTGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCAcc > 1:1050727/6‑100 (MQ=255) aTAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCAcc < 1:161002/100‑1 (MQ=255) tgagggggCGTCTGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCAccc > 1:2332541/5‑100 (MQ=255) aGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCAcccc < 1:937755/100‑1 (MQ=255) aGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCAcccc < 1:940515/100‑1 (MQ=255) agggggCGTCTGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCa > 2:1011234/3‑100 (MQ=255) ggggCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCatc < 2:253949/100‑1 (MQ=255) ggggCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCatc < 2:1027559/100‑1 (MQ=255) ggggCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCatc < 2:963304/100‑1 (MQ=255) ggCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTGCCACAAGAGTACCGATTTCCACCCCatcaa > 1:704271/1‑100 (MQ=255) gCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCatcaat < 1:2179295/100‑1 (MQ=255) tCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCATCAATCag > 1:52754/1‑100 (MQ=255) | TTTGCTGGTATCGGTAAAAAAACTGCTGGCGGAGAATTTTCCGGATGGTGTGTTACGTCCGGGATTCGCCTGAGTAAACTTCCCGCATAGTGGGGCGTCAGACGCCCCCTCAAACATTAAAATGTGAGCACTTTATCGGCTGACAGCGTCCATTGCGCCAGTTCCACAAGAGTACCGATTTCCACCCCATCAATCAG > NC_000913/1273130‑1273326 |
Alignment Legend |
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Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 12 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 41 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |