| Predicted mutation | ||||||
|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | annotation | gene | description |
| RA | NC_000913 | 3,960,578 | 2 bp→CG | coding (1266‑1267/1485 nt) | gppA ← | guanosine pentaphosphatase |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_000913 | 3,960,578 | 0 | G | C | 98.5% | 354.0 / NA | 137 | L423V (CTC→GTC) | gppA | guanosine pentaphosphatase |
| Reads supporting (aligned to +/- strand): ref base G (2/0); new base C (61/74); total (63/74) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 2.10e-01 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 1.00e+00 | |||||||||||
| * | NC_000913 | 3,960,579 | 0 | C | G | 98.5% | 358.2 / NA | 136 | R422R (CGG→CGC) | gppA | guanosine pentaphosphatase |
| Reads supporting (aligned to +/- strand): ref base C (2/0); new base G (59/74); total (62/74) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 2.02e-01 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 1.00e+00 | |||||||||||
Only 100 of 137 total aligned reads displayed.
GCACGAGATCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑GCCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGCAGTA > NC_000913/3960506‑3960646 || gCACGAGATCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAACCGGCAGAGTCGTTCTCCGA‑Gccc > 2:2045424/1‑75 (MQ=255) gagaTCGTCGCGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCgcggc < 2:91462/76‑1 (MQ=255) gagaTCGTCACGTCGACGGCGTGCAAAAATGATGGACAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCgcggc < 2:3834868/76‑1 (MQ=255) gagaTCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCgcggc < 1:2393079/76‑1 (MQ=255) agaTCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCgcggcg < 1:3878870/76‑1 (MQ=255) agaTCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCgcggcg < 2:3194705/76‑1 (MQ=255) gaTCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGcggcgg > 1:3353393/1‑76 (MQ=255) aTCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGCGTTGTTCTGCGA‑CCCGcggcggg > 2:520834/1‑75 (MQ=255) aTCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGt < 2:2971753/76‑1 (MQ=255) tCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGcggcgggc > 2:4178546/1‑74 (MQ=255) tCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTa > 2:2197665/1‑76 (MQ=255) gcGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTa < 2:2102977/75‑1 (MQ=255) gTCACGGCGCCGGCTGGCAAAAATGATGGCCAGGCGGAGTAAACGGCAGAGTTGTGCTGCGG‑CGCGCGGTGGTAcc > 1:4821186/1‑75 (MQ=255) gTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACg < 1:4520042/76‑1 (MQ=255) aCGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCa < 2:2146673/76‑1 (MQ=255) aCGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCa < 1:362695/76‑1 (MQ=255) aCGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCa > 2:864905/1‑76 (MQ=255) aCGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCa > 2:1846933/1‑76 (MQ=255) cGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCGGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCAt < 1:4590865/76‑1 (MQ=255) cGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCAt < 1:4746521/76‑1 (MQ=255) ggCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCAtt > 1:2568171/1‑76 (MQ=255) gCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCAttt > 2:4319307/1‑76 (MQ=255) gCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCAttt < 1:4452485/76‑1 (MQ=255) gCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCAttt < 2:4263040/76‑1 (MQ=255) gggcGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCAtttt < 2:274522/73‑1 (MQ=255) cGACGGCTGGCAAAAACGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGGGGGACGGCAtttt > 2:1472862/1‑76 (MQ=255) gACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTg > 1:586660/1‑76 (MQ=255) gACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTg < 2:1028316/76‑1 (MQ=255) gACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTg < 2:3457903/76‑1 (MQ=255) gACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTg < 1:1591443/76‑1 (MQ=255) gACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAAAGGCAGAGCTGGTCTGCGACGCCG‑GGCCGAACGGCATTTTg > 1:651327/1‑76 (MQ=255) aCGGCTTGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CTCGCGGCGGTACGGGATTTTga > 2:1628783/1‑75 (MQ=255) aCGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCTGCGGTACGGCATTTTGc > 1:1839774/1‑76 (MQ=255) aCGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGc > 1:1805710/1‑76 (MQ=255) aCGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGc < 1:4531839/76‑1 (MQ=255) cGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCt < 1:2729834/76‑1 (MQ=255) ggCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTg > 2:3821884/1‑76 (MQ=255) ggCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGGACGGCATTTTGCTg > 2:3621011/1‑76 (MQ=255) cTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTCCGGCATTTTGCTGAt > 2:1711392/1‑76 (MQ=255) cTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTgct > 2:1989615/1‑74 (MQ=255) cTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGAt > 1:1361150/1‑76 (MQ=255) tGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGctgctg > 2:2317401/1‑76 (MQ=255) tGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTgctc > 2:2298850/1‑73 (MQ=255) tGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGGTg > 1:83459/1‑76 (MQ=255) tGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGGACGGCCTTTTGCTGATg > 2:391125/1‑76 (MQ=255) ggCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGc < 1:2716296/76‑1 (MQ=255) ggCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGc < 1:4430834/76‑1 (MQ=255) gCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCa < 2:174738/76‑1 (MQ=255) cAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATTCAg > 1:1983009/1‑76 (MQ=255) cAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAg < 1:87306/76‑1 (MQ=255) aaaaaTGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGc < 1:3649041/76‑1 (MQ=255) aaaaaTGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGc > 2:3312529/1‑76 (MQ=255) aaaaaTGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGACGCTGCAGc > 2:3343732/1‑76 (MQ=255) aaaTGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTTCTGATGCAGCGa > 2:4632564/1‑76 (MQ=255) aaTGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGAt < 2:497892/76‑1 (MQ=255) aaTGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGAt < 1:1846934/76‑1 (MQ=255) aggatgGCCAGGCGTAGGAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATg < 2:140242/74‑1 (MQ=255) tgatgGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATga < 2:2852563/76‑1 (MQ=255) gatgGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATgag < 1:3094171/76‑1 (MQ=255) atgGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATgaga < 1:1102265/76‑1 (MQ=255) atgGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATgaga < 1:2981523/76‑1 (MQ=255) tgGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATgagag > 1:2890453/1‑76 (MQ=255) gCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGAt > 2:2740963/1‑76 (MQ=255) gCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGAt < 2:1257628/76‑1 (MQ=255) ccAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATc < 1:4283940/76‑1 (MQ=255) ccAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATc < 1:3133/76‑1 (MQ=255) ccAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATc < 1:3348894/76‑1 (MQ=255) aGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGa < 1:2547961/76‑1 (MQ=255) ggCGTAGTAAACGGCAGAGTTGCTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGAc > 1:4136458/1‑76 (MQ=255) gCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGAcc > 2:3773143/1‑76 (MQ=255) gCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGAcc < 1:3449330/76‑1 (MQ=255) gCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGAcc < 2:4485028/76‑1 (MQ=255) gCGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGAcc < 1:2924752/76‑1 (MQ=255) cGTAGTAAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCg < 1:970272/76‑1 (MQ=255) gtagtaAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCgg > 2:3708656/1‑76 (MQ=255) tagtaAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGa > 1:4803484/1‑76 (MQ=255) gtaAACGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGAtt < 1:1191179/76‑1 (MQ=255) taAACGGCAGAGTTGTTCTGAGA‑CGCGCGGCGGTACAGCCTTTTGCTGATGCAGCGTTGAGAGATCGACCGGATTa > 2:4701479/1‑76 (MQ=255) taAACGGCAGAGTTGCTCTGCGA‑CGCGCCGCGGTACGGCACTTTGATGATGCAGCGATGCGACACCGCCCGGCTTa > 2:1050952/1‑76 (MQ=255) aaaCGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAg > 2:1567284/1‑76 (MQ=255) aaaCGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAg > 1:213920/1‑76 (MQ=255) cGGCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCt < 2:357349/76‑1 (MQ=255) tcAGAGTTGTTCTGCGA‑CGCGCGGCGTTACGGCGTTTGGCTGATGCAGCGATGAGAGATCGCCCGGATGAGGCTgg < 1:1647563/75‑1 (MQ=255) gCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTgg < 1:1640999/76‑1 (MQ=255) gCAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTgg > 1:4194285/1‑76 (MQ=255) cAGAGTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGt < 1:2236186/76‑1 (MQ=255) agagTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGtt > 2:4482340/1‑76 (MQ=255) agagTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGtt > 2:2751266/1‑76 (MQ=255) gagTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTg < 1:3827153/76‑1 (MQ=255) gagTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTg < 1:1062219/76‑1 (MQ=255) gagTTGTTCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTg < 1:86321/76‑1 (MQ=255) gagTTGTTCTGCGA‑CGCGCGGCGGTACGGCACTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTg < 2:2841433/76‑1 (MQ=255) ttgttCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGc < 2:2169859/76‑1 (MQ=255) ttgttCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGc > 2:669313/1‑76 (MQ=255) tgttCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGCACGGATTAGTCTGGTTGCGCa > 2:3002071/1‑76 (MQ=255) tgttCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGCa > 2:2997188/1‑76 (MQ=255) ttCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGCAGt < 1:3114480/76‑1 (MQ=255) ttCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGCAGt > 1:3861046/1‑76 (MQ=255) tCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGCAGtg > 2:4668477/1‑75 (MQ=255) tCTGCGA‑CGCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGCAGTa < 1:1776864/76‑1 (MQ=255) || GCACGAGATCGTCACGGCGACGGCTGGCAAAAATGATGGCCAGGCGTAGTAAACGGCAGAGTTGTTCTGCGA‑GCCGCGGCGGTACGGCATTTTGCTGATGCAGCGATGAGAGATCGACCGGATTAGTCTGGTTGAGCAGTA > NC_000913/3960506‑3960646 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 9 ≤ ATCG/ATCG < 23 ≤ ATCG/ATCG < 40 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |