| Predicted mutation | |||||||
|---|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | freq | annotation | gene | description |
| RA | NC_000913 | 847,213 | A→T | 7.4% | intergenic (‑94/+45) | glnP ← / ← glnH | L‑glutamine ABC transporter membrane subunit/L‑glutamine ABC transporter periplasmic binding protein |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_000913 | 847,213 | 0 | A | T | 7.4% | 155.2 / 2.2 | 59 | intergenic (‑94/+45) | glnP/glnH | L‑glutamine ABC transporter membrane subunit/L‑glutamine ABC transporter periplasmic binding protein |
| Reads supporting (aligned to +/- strand): ref base A (26/25); new base T (2/2); total (28/31) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 1.00e+00 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 8.33e-01 | |||||||||||
TCAGAAGCGGAATGGCAGGCCAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGACTTTGTCACGCAGCT > NC_000913/847074‑847355 | tCAGAAGCGGAATGGCAGGCCAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑g > 1:286147/1‑143 (MQ=255) gAATGGCAGGCCAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCC‑TATGGGGAGAgga < 1:174695/143‑2 (MQ=255) aTGGCAGGCCAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAACCCTCTCCCC‑TATGGGGAGAggatt < 1:446866/143‑4 (MQ=255) tGGCAGGCGAGATGGCACTCCAGGCAAACCGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAAGGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAAc < 1:122750/143‑1 (MQ=255) gCAGGCCATATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAACCCTCTCCCCTAT‑GGGGAGAggattagg < 1:385394/143‑7 (MQ=255) cAGGCCAGAGAGCACTCCAGTCAGACTGCATATGTTGCTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGc < 2:584479/143‑1 (MQ=255) ggCCAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGTGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCa < 1:331970/143‑1 (MQ=255) gCCAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTACTGTTCCCTGTTCGGGTTTGCGCCCCGCCCCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGccgg > 1:411457/1‑141 (MQ=255) cAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GCGGAGGGGAAACTGCCCGTg > 2:816193/1‑143 (MQ=255) cTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACa > 1:513993/1‑143 (MQ=255) cAGTCCAACGTCATATGTTGTGCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCTGAGCGGGTTTGCGCCCCTCACCCTCATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGgt < 2:826041/143‑1 (MQ=255) cAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGgt > 1:1074656/1‑143 (MQ=255) cAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGgt < 1:381943/143‑1 (MQ=255) cAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAAACAAATTCAGGGTAATTAATGGCCCCGGAGCGGGATTGCCCCCCTCACCCTAATCCCCTCCCCATA‑GGAGAACGCGACCAGCCAGCGCGGCTTACACgt > 2:732810/1‑143 (MQ=255) aGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTACCCAACTAACCTTA‑GTGGGTAGGGAACTGCCAGTGCGTTTTACAGgtg < 1:1052656/143‑1 (MQ=255) aaCTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCg > 1:782168/1‑143 (MQ=255) tatGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTtattat > 1:1031524/1‑143 (MQ=255) gttgttCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCGGGAGCGGGTTTGCGCCCCTCACCCTACTCCTCTCCCGATA‑GGGGAGAGGGAACTGCCACTGCGTCTCACAGGTGTAGCGTTATTATTTc > 2:999723/1‑143 (MQ=255) ttgttCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCg < 1:59303/143‑1 (MQ=255) ttgttCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCACCTCAACCTAATCATCTCCCAACA‑GGGGAGAGGGAAGTGCCAGTGCGTTGTCCAGGTGTGGCGATATTATATCg > 2:652598/1‑143 (MQ=255) ttCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGtt < 2:741970/143‑1 (MQ=255) gtggtgTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAAc > 1:603379/1‑143 (MQ=255) tggtgTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCCCACCCTAATCCTCTCCCCATA‑GGGGCGAGGGAACTGCCAGTGCGTCTTACCGGTGTCGCGTTTTTATTTCGGTTCAGTACCGAGcc > 1:973422/1‑143 (MQ=255) tAAATAATCAAATTCGGGGTACCTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCAtttt < 2:716718/143‑1 (MQ=255) aataatCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCAtttttt > 1:762811/1‑143 (MQ=255) taatGAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑TGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGt < 2:245428/143‑1 (MQ=255) tgtCAAATTCGCGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTTACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTa < 2:12237/141‑1 (MQ=255) tgacactCAGGGTAAGTAATGGCCGCGGATCGGGTTTGCGCCCTTCACCCTCATCCTCTCCCCGTA‑GGGGAGACGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGa < 2:436624/137‑1 (MQ=255) tCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCGTCTCCCCATA‑GGGGAGAGGGGACTGCCAGTGCGTTTTACAGGGGAAGCGATATTATTTCGGTCAAGCACCGACCCATCTTTAGtcgg > 2:1061730/1‑140 (MQ=255) tCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGGTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGa < 1:970200/143‑1 (MQ=255) cAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGAt > 2:1025009/1‑143 (MQ=255) aaaTTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCGCTCCGCATC‑GGGGAGAGGGAACTGCCCGTGCGTTTTCCAGGTCTAGCGTTACTATTTCCGTTCAGTACCGAACCATTTTTTGTAGAtt > 2:374872/1‑143 (MQ=255) aatgcggggCAATTCATGGCCCCGGAGGGGGTTAACCACCTTCACGCGAGGTCCCTCCCGATA‑GGGGATAGGGACCTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGAttt < 2:779645/137‑1 (MQ=255) tCAGGGTAATTAGTGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGt < 2:4107/143‑1 (MQ=255) cAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGtt < 2:592146/143‑1 (MQ=255) cAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGtt < 1:341878/143‑1 (MQ=255) cAGGGTAATTAATGGCCCCGGAGCGGGTGTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGtt < 1:352539/143‑1 (MQ=255) cAGCGTAATTAATGGCCCCTGAGCTGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGtt < 1:168794/143‑1 (MQ=255) aatGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCg < 2:409493/143‑1 (MQ=255) ccccGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGCGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAGGTTCCGTtctc > 2:992597/1‑143 (MQ=255) cccGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTATATTTCGTTGTAAGATCCGTTCTcg > 1:870673/1‑143 (MQ=255) ccGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCGGTTCTcgc > 1:534960/1‑143 (MQ=255) gCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAgg < 2:1089791/143‑1 (MQ=255) gggTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGCGGAGACTGCCAGTGCGTTTTACAGGAGTAGCGATATTATTTCGCTTCAGGATCGAACAATTGTTTGTAGATTACGTATTAAGTTACAATCTCACGCAGGGt > 2:885468/1‑143 (MQ=255) cgcCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAAc > 2:889073/1‑143 (MQ=255) ccccTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAAcgc < 1:1025009/143‑1 (MQ=255) ccccTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAAcgc < 1:327253/143‑1 (MQ=255) tCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCg > 2:565502/1‑143 (MQ=255) cACCCTAACCCTCTCCCCATA‑GGCGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGt < 1:999723/143‑1 (MQ=255) cccTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTg < 1:953430/143‑1 (MQ=255) ccTAGTCCTCTCGCCGTG‑GGGGAGAGGGAACTGCCAGTGCTTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGa < 2:364819/143‑1 (MQ=255) ccTAATCGTCTCCCCATA‑GGGGAGAGGGAGCTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATGTCGTTGTAAGTTCAGTTCTCGCGCATGGTTTTCAACGCGCCGTTGa < 2:578292/143‑1 (MQ=255) cTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGCTTTAGTTGTGAGTCCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGAc > 2:779745/1‑143 (MQ=255) tAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTTAACGCTCCGTTGatt > 1:685188/1‑141 (MQ=255) tAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTAGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGACt > 1:989507/1‑143 (MQ=255) ttcccTCTCCCCTAT‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATATGGGCTCAGGACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGACtt > 1:156267/4‑143 (MQ=255) aaTCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGATGGTTCTACGCGCCGTAGACtt > 1:744291/1‑143 (MQ=255) ctctCCCCTAT‑GGGGAGAGGGAACTGCCGGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGCACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGACTTTGTc > 1:364113/1‑143 (MQ=255) tcCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGCTGACTTTGTCACg < 2:762811/143‑1 (MQ=255) aTA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGACTTTGTCCCGGAGCt > 1:1044986/1‑143 (MQ=255) | TCAGAAGCGGAATGGCAGGCCAGATGGCACTCCAGTCAAACTGCATATGTTGTTCCTGTTACCGTGGTGTAAATAATCAAATTCAGGGTAATTAATGGCCCCGGAGCGGGTTTGCGCCCCTCACCCTAATCCTCTCCCCATA‑GGGGAGAGGGAACTGCCAGTGCGTTTTACAGGTGTAGCGTTATTATTTCGGTTCAGTACCGAACCATTTTTTGTAGATTTCGTTGTAAGTTCCGTTCTCGCGCAGGGTTTTCAACGCGCCGTTGACTTTGTCACGCAGCT > NC_000913/847074‑847355 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 8 ≤ ATCG/ATCG < 12 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 41 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |