| Predicted mutation | |||||||
|---|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | freq | annotation | gene | description |
| RA | NC_000913 | 3,510,368 | T→G | 10.1% | G203G (GGA→GGC) | yhfX ← | putative PLP‑binding protein YhfX |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_000913 | 3,510,368 | 0 | T | G | 10.1% | 165.4 / 7.4 | 58 | G203G (GGA→GGC) | yhfX | putative PLP‑binding protein YhfX |
| Reads supporting (aligned to +/- strand): ref base T (25/27); new base G (4/2); total (29/29) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 6.70e-01 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 1.00e+00 | |||||||||||
CACACCGTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATAAAGAAAATC > NC_000913/3510227‑3510508 | cacaCCGTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGAAAAGTTTTGCCGACacc < 1:977974/150‑3 (MQ=255) cacCGTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCt < 2:1296969/150‑1 (MQ=255) cacCGTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCAGAAAGcca > 2:174213/1‑149 (MQ=255) acCGTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGAAAAGTTTTGCCGACaccgaa < 1:455188/150‑6 (MQ=255) cGTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCAt < 1:1224503/150‑1 (MQ=255) gTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATc > 1:480490/1‑150 (MQ=255) aTTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATccc < 1:508107/150‑1 (MQ=255) gcgcCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCaaa > 2:1342081/1‑150 (MQ=255) gcgcCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCaaa < 1:967452/150‑1 (MQ=255) gcCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGc < 1:242638/150‑1 (MQ=255) cAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAg > 1:596887/1‑150 (MQ=255) aGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCATGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAgg < 1:439115/150‑1 (MQ=255) tAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCGGGCa < 1:240978/150‑1 (MQ=255) gCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGa > 1:1298170/1‑150 (MQ=255) aGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACCGCCTCATCCCAAAGCAGGCAAGGGaaa > 1:1121184/1‑150 (MQ=255) tGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCgg > 1:228620/1‑150 (MQ=255) gTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCt < 2:1298170/150‑1 (MQ=255) tCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCCGTGTCGCCAAAACTATTAAAACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTa > 2:1218848/1‑150 (MQ=255) aGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAg < 1:861636/150‑1 (MQ=255) aGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGa > 2:1148383/1‑150 (MQ=255) tCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTgg < 1:954937/150‑1 (MQ=255) cAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGa < 1:900300/150‑1 (MQ=255) cAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTACGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGa > 2:642040/1‑150 (MQ=255) aGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGAtt < 1:1342081/150‑1 (MQ=255) tGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTc < 1:897160/150‑1 (MQ=255) aaTACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGc < 2:272218/150‑1 (MQ=255) aTACCAGATTTCGCCAGTTGATCCCGTGTCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCg < 2:315903/150‑1 (MQ=255) aTACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTAGGTTTCTGCAAAACTATTAAAACATACTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCg > 2:966317/1‑150 (MQ=255) aCCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGAc < 1:323648/150‑1 (MQ=255) ccAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATAACGTTTCTCCACAAATAATAAAAAAAAATAATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACa > 2:408625/1‑150 (MQ=255) cGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCgg > 1:1330294/1‑150 (MQ=255) ccAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCa < 1:994337/150‑1 (MQ=255) ttGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAacac < 1:1216408/150‑1 (MQ=255) tGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACAcc > 1:25234/1‑150 (MQ=255) gATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCt > 1:743707/1‑150 (MQ=255) gATCCCGTGCCTGTATCAGCGTGTGAAGATTAGGTGTCGGCAAAACTTTTCAGAAAGCCTCATCCCAAAGCAGGTAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCt > 2:550153/1‑150 (MQ=255) gATCCCGTGCCTGTATCAGCGTGTGAAGATTACGTGTCTGCAAAACTATTCCGAAAGCATCATCCCAAAGCAGGTAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCt > 2:554934/1‑150 (MQ=255) tCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTg < 2:645991/150‑1 (MQ=255) ccGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAg > 1:672758/1‑150 (MQ=255) gTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAggg < 1:66456/150‑1 (MQ=255) gTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAggg < 1:1275162/150‑1 (MQ=255) aTCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAACAGGCAAGGGAAATGGGT‑AGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGc > 1:888658/1‑150 (MQ=255) aGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGctc < 2:596887/150‑1 (MQ=255) aGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGctc < 1:1148383/150‑1 (MQ=255) tgtgAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTGGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCt > 1:1290671/1‑150 (MQ=255) tgtgAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCt < 1:800483/150‑1 (MQ=255) tgAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTgg > 1:266585/1‑150 (MQ=255) gAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGc > 1:330923/1‑150 (MQ=255) aTTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCgg < 2:672758/150‑1 (MQ=255) gaggctgtCGGAAAAGTTTTGCCGACAGTCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGa > 2:937716/6‑150 (MQ=255) cGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATa > 2:285142/1‑150 (MQ=255) gctgtCGGAAAAGTTTTGCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATaa > 1:186165/3‑150 (MQ=255) gctgtCGGAAAAGTTTTGCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATaa > 2:829643/3‑150 (MQ=255) gctgtCGGAAAAGTTTTGCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAAACTCCGGCAACACCTTCAGGGCAAAAACGCTCGCCGGGCCCGGAGaa > 2:1091796/3‑150 (MQ=255) gtgtCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATaaa < 1:642040/150‑1 (MQ=255) gtgtCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATaaa < 1:608542/150‑1 (MQ=255) gCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATAAAGAAAat > 1:1149877/1‑150 (MQ=255) cAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATAAAGAAAatc > 2:981308/1‑150 (MQ=255) | CACACCGTATTGCGCCAGTAATGGCAGCGAAGTGCAGCTGGTCGCTGAAGGCGCGTTCAGTTGCTCAAGTGCAATACCAGATTTCGCCAGTTGATCCCGTGCCTGTATCAGCGTGTGAAGATTCGGTGTCGGCAAAACTTTTCCGACAGCCTCATCCCAAAGCAGGCAAGGGAAATGGGTAAGTCCGGCTAAATGCAGCCCTGGCAGATTCTGGATTTCGGCGACAATCTCCGGCAACACCTTGAGGGCAAAACCGCTCTCCTGGCCCGGATAAAGAAAATC > NC_000913/3510227‑3510508 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 14 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 36 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |