| Predicted mutation | |||||||
|---|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | freq | annotation | gene | description |
| RA | NC_002947 | 4,360,763 | C→T | 7.7% | G120D (GGC→GAC) ‡ | PP_3835 ← | two‑component system sensor histidine kinase |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_002947 | 4,360,763 | 0 | C | T | 7.7% | 151.5 / 2.4 | 52 | G120D (GGC→GAC) ‡ | PP_3835 | two‑component system sensor histidine kinase |
| Reads supporting (aligned to +/- strand): ref base C (26/22); new base T (2/2); total (28/24) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 1.00e+00 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 9.72e-01 | |||||||||||
AACATGTTGTTGAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCATCCG > NC_002947/4360616‑4360910 | aaCATGTTGTTGAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTggccaggc > 1:196566/1‑148 (MQ=255)aaCATGTTGTTGAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTggccaggc < 6:348743/148‑1 (MQ=255) gttgttGAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGa > 5:242804/1‑149 (MQ=255) gttgAAGTCGTGCGCCAGACCAGCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATc < 6:242804/148‑1 (MQ=255) gttgAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTggccaggcc > 5:242651/1‑141 (MQ=255) gttgAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTggccaggcc < 6:242651/141‑1 (MQ=255) ttgAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCt < 3:346953/148‑1 (MQ=255) ttgAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTg > 8:158526/1‑149 (MQ=255) tCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGATCATTGGCCTGGCCaag < 7:264338/149‑3 (MQ=255) cgcCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTtca < 4:299952/148‑1 (MQ=255) gcCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTtcatc > 6:336583/1‑149 (MQ=255) gcCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTtcat > 2:345938/1‑148 (MQ=255) caccGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTTGCCACTTTCATCACGGATc < 5:8229/149‑1 (MQ=255) caccGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATc < 2:196566/149‑1 (MQ=255) cTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTgg < 1:145143/121‑1 (MQ=255) cTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTg > 2:278698/1‑149 (MQ=255) cTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCAgg > 2:145143/1‑121 (MQ=255) cGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTgccgc > 7:240149/1‑148 (MQ=255) gCTTGAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGc < 4:111108/149‑1 (MQ=255) ttCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATca > 2:331289/1‑128 (MQ=255) ttCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATca < 1:331289/128‑1 (MQ=255) gCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAAc > 4:243649/1‑149 (MQ=255) gCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAAc > 3:290597/1‑149 (MQ=255) ttCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTtcatca > 6:296277/1‑114 (MQ=255) ttCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTtcatca < 5:296277/114‑1 (MQ=255) cgcCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTg < 8:220657/148‑1 (MQ=255) cgcCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTg < 1:345938/148‑1 (MQ=255) cgcCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGc < 3:243649/149‑1 (MQ=255) gAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCt > 2:329496/1‑149 (MQ=255) aCAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTg > 7:327291/1‑149 (MQ=255) cAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCTTCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTgc < 1:278698/149‑1 (MQ=255) cTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCa > 6:109596/1‑149 (MQ=255) aCTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCACCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGcc > 5:148083/1‑149 (MQ=255) gTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGt < 8:327291/149‑1 (MQ=255) tCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTc < 8:240149/149‑1 (MQ=255) gctgcGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTgcgc > 2:144244/1‑148 (MQ=255) gcgACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTc < 5:109596/147‑1 (MQ=255) gcgACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCa < 3:83128/149‑1 (MQ=255) gACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAgc > 3:256603/1‑149 (MQ=255) ggTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGcc < 4:290597/149‑1 (MQ=255) ggTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGcc > 3:160668/1‑149 (MQ=255) tCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCa < 2:315326/113‑1 (MQ=255) tCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCa > 1:315326/1‑113 (MQ=255) tCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCa < 6:220990/113‑1 (MQ=255) tCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCa > 5:220990/1‑113 (MQ=255) gTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGca > 2:227266/1‑149 (MQ=255) tCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCAcagca < 5:336583/148‑1 (MQ=255) tCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCAcag > 2:276186/1‑146 (MQ=255) tCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCAcag > 1:186918/1‑146 (MQ=255) aCCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCCCAgg > 7:271791/1‑149 (MQ=255) ccTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAggg > 4:151808/1‑149 (MQ=255) aagtGGCCAGATCATTGGCCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAggg > 8:45075/4‑149 (MQ=255) cTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGc < 1:15152/70‑1 (MQ=255) cTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGc > 2:15152/1‑70 (MQ=255) gtGGCCAGATCATTGGCCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCg < 3:319578/98‑1 (MQ=255) gtGGCCAGATCATTGGCCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCg > 4:319578/2‑99 (MQ=255) ggccaggccaATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGggcg < 1:144244/147‑1 (MQ=255) ccaggccaATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCa > 7:148001/1‑149 (MQ=255) aggccaATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCATc > 3:38145/1‑149 (MQ=255) aggccaATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCATc > 6:125111/1‑149 (MQ=255) aggccaATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACACGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCATc > 8:300775/1‑149 (MQ=255) gccaATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCATCCg > 8:324382/1‑149 (MQ=255) gccaATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGAGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCATCCg > 2:141157/1‑149 (MQ=255) | AACATGTTGTTGAAGTCGTGCGCCAGACCACCGGTCAACTGGCCGAGGGCTTCAAGCTTCTGCGCCTGGAACAGCTGGGCGCGCACTGCGTCGAGCTGCTGCGCCGTCTCGCGACGGTCAGTGATATCACGTGTCACCTTGGCCAGGCCAATGATCTGGCCACTTTCATCACGGATCACATCCAGTGCCGCCAAGGCCCAGAACTGCGTGCCGTCCTTGCGCACCCGCCAGCCTTCGTCCTGCGCCACACCTTGCTCCAGCGCCTGGCACAGCAGACGCTCAGGGCGGCCATCCG > NC_002947/4360616‑4360910 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 14 ≤ ATCG/ATCG < 27 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 36 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |