| Predicted mutation | |||||||
|---|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | freq | annotation | gene | description |
| RA | NC_002947 | 5,602,162 | T→A | 6.5% | E440D (GAA→GAT) | PP_4924 ← | subtilase family serine protease |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_002947 | 5,602,162 | 0 | T | A | 6.5% | 186.9 / 3.3 | 61 | E440D (GAA→GAT) | PP_4924 | subtilase family serine protease |
| Reads supporting (aligned to +/- strand): ref base T (33/24); new base A (2/2); total (35/26) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 1.00e+00 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 9.21e-01 | |||||||||||
CTGACGCACCTCTCCTACCGGCTCGACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGACGTTGCTCACCTGGC > NC_002947/5602018‑5602310 | cTGACGCACCTCTCCTACCGGCTCGACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCaa > 2:217952/1‑149 (MQ=255) gCACCTCTCCTACCGGCTCGACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTCAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGtt > 2:148361/1‑148 (MQ=255) ccTCTCCTACCGGCTCGACCTGTCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCGATTG‑CGCCCAGACGGCGTCTTCAACGTtgatg < 8:43387/149‑1 (MQ=255) cTACCGGCTCGACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCATCAACGTTGAAGACGc < 7:226600/147‑1 (MQ=255) tACCGGCTCGACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCAt > 7:184187/1‑149 (MQ=255) tCGACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGAc > 4:132958/1‑137 (MQ=255) gACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTGCCGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGtt < 1:64740/148‑1 (MQ=255) gACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGACATCGGCACGCCCGTAGTGGTTGCCATCGACCCACACATTCAATTG‑CGCCCAGACGGCGTCTTAAACGTTGATGACGCCAACGGCGTTgg > 7:204276/1‑149 (MQ=255) cTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGTCGTTGGCGt < 6:28919/149‑1 (MQ=255) cTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCAACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGt < 7:148934/149‑1 (MQ=255) cGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGAAGCCATCGCCCTTGGCGTCAac > 7:293303/1‑148 (MQ=255) gAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAacac > 4:64746/1‑149 (MQ=255) cTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTg > 8:223086/1‑149 (MQ=255) aaTGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGggcggc > 2:142837/1‑147 (MQ=255) aaTGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGggcggc < 1:142837/147‑1 (MQ=255) aTGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGaa < 1:217952/149‑1 (MQ=255) tGCCATGCTCCTGCAATGCCCTCAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAg < 1:148361/149‑1 (MQ=255) ccATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCATCAACGTTGAAGACGcc > 6:193636/1‑110 (MQ=255) ccATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCATCAACGTTGAAGACGcc < 5:193636/110‑1 (MQ=255) aTGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGaa < 8:230092/144‑1 (MQ=255) aTGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCAt > 2:31240/1‑149 (MQ=255) aTGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCAGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGaa > 7:230092/1‑144 (MQ=255) tCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCtt > 4:46203/1‑149 (MQ=255) cTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTg > 7:10652/1‑148 (MQ=255) cAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGaa < 8:89967/147‑1 (MQ=255) aaTGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACgg > 3:155377/1‑149 (MQ=255) cTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGttt > 3:258297/1‑148 (MQ=255) aGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTg < 4:127095/99‑1 (MQ=255) aGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTg > 3:127095/1‑99 (MQ=255) tCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCa > 1:33938/1‑147 (MQ=255) tCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCa > 4:92271/1‑147 (MQ=255) tCACCGGCAGCGGCACGGCCGTCGTGGGTGCGATCGACGCGCCCCTGCAATTG‑CGCCGAGACGGCGTCTTCAGCGTTGATGACGCGATGGGCGTTGGCGTCAGCAGTGGCCAGGGCGGCGAGGCCATCCTTGAACGGCGTTTCACCa > 6:241765/1‑147 (MQ=255) ggCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGc < 7:223086/149‑1 (MQ=255) gaaTCGGCACGCCCGTCGTGGTTGCCATCGAACCAAACCTTCAATTG‑CGCCCAGACGTCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTTCCAGGGCGGCGAAGTCATCCTTGATCGTCGTTTCACCAGAGCTGcc < 8:204276/147‑1 (MQ=255) cGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCa > 1:324356/1‑149 (MQ=255) ggCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCa < 2:127470/148‑1 (MQ=255) aCGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCActgc > 2:65921/1‑149 (MQ=255) ccGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCActgcctgc > 5:176853/1‑149 (MQ=255) ccGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCActgcctgc > 7:241317/1‑149 (MQ=255) gtGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTgc > 3:205410/1‑149 (MQ=255) ccATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCgta < 4:317157/149‑1 (MQ=255) ccATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCgta < 3:92271/149‑1 (MQ=255) cATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCgtag > 4:260681/1‑149 (MQ=255) aTCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCgtag > 7:19131/1‑148 (MQ=255) tCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCt < 8:71611/119‑1 (MQ=255) tCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCgtagta < 8:293303/149‑1 (MQ=255) aCCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTc < 3:46203/149‑1 (MQ=255) aCCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTc < 1:65921/149‑1 (MQ=255) cccACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTc < 4:155377/148‑1 (MQ=255) cccACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCg < 8:10652/149‑1 (MQ=255) ccACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAacac > 4:118674/1‑68 (MQ=255) ccACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAacac < 3:118674/68‑1 (MQ=255) acacCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCg > 7:177566/1‑146 (MQ=255) acacCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGgag < 8:241317/149‑1 (MQ=255) cTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGaa > 6:224806/1‑147 (MQ=255) ttCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAg > 6:316761/1‑149 (MQ=255) gcCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGAc > 2:292592/1‑149 (MQ=255) ccAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGACGt > 8:48584/1‑149 (MQ=255) aGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGACGTTg > 1:35618/1‑149 (MQ=255) gCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGACGTTGCTCAc < 8:184187/149‑1 (MQ=255) cGTCATCAACGTTGAAGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCCCTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGACGTTGCTCAcc > 5:172077/1‑149 (MQ=255) ttCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGACGTTGCTCACCTGGc > 5:313873/1‑149 (MQ=255) | CTGACGCACCTCTCCTACCGGCTCGACCTGGCCGAGCTTGATCTGGCTAATGCCATGCTCCTGCAATGCCCTTAGCTCACCGGCATCGGCACGCCCGTCGTGGTTGCCATCGACCCACACCTTCAATTG‑CGCCCAGACGGCGTCTTCAACGTTGATGACGCCATCGGCGTTGGCGTCAACACTTGCCAGGGCGGCGAAGCCATCCTTGAACGGCGTTTCACCAGAGCTGCCATCACTGCCTGCCTTGCCGCCGTAGTATTCGGAGAACAGCTGGCTGACGTTGCTCACCTGGC > NC_002947/5602018‑5602310 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 14 ≤ ATCG/ATCG < 27 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 36 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |