| Predicted mutation | |||||||
|---|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | freq | annotation | gene | description |
| RA | NC_002947 | 652,767 | G→C | 13.5% | intergenic (‑104/+14) | dsbD‑I ← / ← ctpL | thiol/disulfide interchange protein 1/methyl‑accepting chemotaxis protein CtpL |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_002947 | 652,767 | 0 | G | C | 13.5% | 155.7 / 13.6 | 59 | intergenic (‑104/+14) | dsbD‑I/ctpL | thiol/disulfide interchange protein 1/methyl‑accepting chemotaxis protein CtpL |
| Reads supporting (aligned to +/- strand): ref base G (27/24); new base C (3/5); total (30/29) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 4.72e-01 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 8.12e-01 | |||||||||||
TGGCCAGCAGTAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTCACCCAGTTCGTGAATCCGCTC > NC_002947/652624‑652903 | tGGCCAGCAGTAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTCCCAGGCATGAGAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGACGGTTTCCCCGCGAAGCGCCGCGCGggcggc > 6:9204/1‑149 (MQ=37) gCCAGCAGTAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCCCGCGCGgcgc > 6:149827/1‑149 (MQ=255) agcagTAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACGCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCCCGCGCGGCGCttc < 8:251486/149‑3 (MQ=255) gcagTAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCCCGCGCGGCGCttcg < 5:149827/149‑4 (MQ=255) gTAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGGAGCGCCGCCCGCGCGGCGCttcgcgg < 1:55770/149‑7 (MQ=38) tAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGAtct > 3:298190/1‑148 (MQ=255) ggAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCgcgggc > 5:126485/1‑134 (MQ=255) ggAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCgcgggc < 6:126485/134‑1 (MQ=255) gAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGa < 4:261187/149‑1 (MQ=255) cATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCAATCTCAGACCCTg > 5:295955/1‑148 (MQ=255) tGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCTGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAAc > 4:133743/1‑149 (MQ=255) gAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACg > 4:29885/1‑149 (MQ=255) cgcATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCg > 3:280547/1‑149 (MQ=255) gcATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGATTAATTGGCGCGAAACAAACGTAGGAGCTGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCGTGAACGCTCGCACCGCCCgg < 1:102424/149‑1 (MQ=255) cATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGt < 4:298190/149‑1 (MQ=255) cATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCCCGCGCGGCGCttcgc > 5:255575/1‑115 (MQ=255) cATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCCCGCGCGGCGCttcgc < 6:255575/119‑5 (MQ=255) aTGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGtt > 6:92839/1‑149 (MQ=255) aTGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGAGCAGGAATAATTGGCCCGATACAAACGTAGGAGCGGGTTTACCCGCGAAGGGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGtt < 5:9204/149‑1 (MQ=255) aCTCGCGAGGTGGAACGTGCCCGGCATGATAACGGTATGCGAAGGAATAATTGGCCCGAAAAAAACGTAGGAGCGGGTTTACCCCCGAAGCGCCGCGCGGCCGGCGATCGATCTCAGACCCTGAACGCt > 1:235201/1‑129 (MQ=25) aCTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCt < 2:235201/128‑1 (MQ=255) cTCGCGAGGTGGAACGTGCCTGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCAc < 3:133743/149‑1 (MQ=255) aaCGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTc > 5:299837/1‑130 (MQ=255) aaCGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTc < 8:115155/130‑1 (MQ=255) aaCGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTc > 7:115155/1‑130 (MQ=255) aaCGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTc < 6:299837/130‑1 (MQ=255) aCGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCgg > 3:296130/1‑126 (MQ=255) aCGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCgg < 4:296130/126‑1 (MQ=255) cccGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGTCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCagcagc < 4:280547/148‑1 (MQ=255) ccGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTg > 4:7368/1‑149 (MQ=255) gATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGATCGATCTCAGACCATGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCAccc > 8:274430/1‑149 (MQ=255) tAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTg < 1:44885/149‑1 (MQ=255) aCGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGt < 3:332215/148‑1 (MQ=255) cGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGtt > 5:223479/1‑148 (MQ=255) gg‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGc < 4:306053/94‑1 (MQ=255) gg‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGc > 3:306053/1‑94 (MQ=255) aTGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACg < 7:31302/149‑1 (MQ=255) cgcAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGccc < 7:211366/149‑1 (MQ=255) gcAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTc > 1:256532/1‑69 (MQ=40) gcAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTc < 2:256532/69‑1 (MQ=40) aGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTc < 1:324165/149‑1 (MQ=255) ttGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATgc > 6:86477/1‑149 (MQ=255) gCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCagcagc > 1:148619/1‑115 (MQ=255) gCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCagcagc < 2:148619/115‑1 (MQ=255) gCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATgcgc < 3:29885/148‑1 (MQ=255) ccGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTg > 2:269646/1‑148 (MQ=255) ccGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTg > 2:49/1‑148 (MQ=255) aaacGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGt > 2:16966/1‑149 (MQ=255) aacGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAgg > 1:88009/1‑144 (MQ=255) aacGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAgg < 2:88009/144‑1 (MQ=255) aacGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAgg < 2:92589/144‑1 (MQ=255) aacGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGtagat > 1:92589/1‑145 (MQ=255) cGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCtt < 3:7368/149‑1 (MQ=255) gAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTCAcc > 4:214291/1‑148 (MQ=255) aCCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTCACCCAGTTCGTGaa > 3:74385/1‑149 (MQ=255) ccGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTCACCCAGTTCGTGAATc > 5:71001/1‑149 (MQ=255) gcgAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTGACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTCACCCAGTTCGTGAATccc > 6:39338/1‑148 (MQ=255) tcgaGCGCCGCCCGCGCGGCGCTTGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTc < 5:287163/127‑1 (MQ=255) tcgaGCGCCGCCCGCGCGGCGCTTGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTc > 6:287163/4‑130 (MQ=255) aaGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTCACCCAGTTCGTGAATCcgctc < 5:86477/149‑1 (MQ=255) ccgcGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTc > 2:228555/1‑123 (MQ=255) ccgcGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTc < 1:228555/123‑1 (MQ=255) | TGGCCAGCAGTAGGAACAGCATGAAAAACAGGCGGCGCATGGCGGACTCGCGAGGTGGAACGTGCCCGGCATGATAACGG‑ATGCGCAGGAATAATTGGCCCGAAACAAACGTAGGAGCGGGTTTACCCGCGAAGCGCCGCGCGGGCGGCGCTCGATCTCAGACCCTGAACGCTCGCACCGCCCGGTTCAGCTCACCGCCCAGGCTCAGCAGCTGTTCACCCTGTTTACGCCCCTCGCCAATGCGCTGCAGGTTGTCTTCACCCAGTTCGTGAATCCGCTC > NC_002947/652624‑652903 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 14 ≤ ATCG/ATCG < 21 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 36 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |