Predicted mutation
evidence seq id position mutation freq annotation gene description
RA NC_002947 521,214 C→T 8.9% E28K (GAA→AAA) ‡ anmK ← anhydro‑N‑acetylmuramic acid kinase

Read alignment evidence...
  seq id position ref new freq score (cons/poly) reads annotation genes product
*NC_002947521,2140CT 8.9% 156.5 / 4.5 56E28K (GAA→AAA) ‡anmKanhydro‑N‑acetylmuramic acid kinase
Reads supporting (aligned to +/- strand):  ref base C (26/25);  new base T (3/2);  total (29/27)
Fisher's exact test for biased strand distribution p-value = 1.00e+00
Kolmogorov-Smirnov test that lower quality scores support variant p-value = 1.57e-01

TTGGCGGATACCTTCGCCGGCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATACGGGCAATCAGCGGCT  >  NC_002947/521068‑521360
                                                                                                                                                  |                                                                                                                                                  
ttGGCGGATACCTTCGCCGGCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCaa                                                                                                                                                  <  6:45554/149‑1 (MQ=255)
  ggCGGATACCTTCGCCGGCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAg                                                                                                                                                 <  2:85367/148‑1 (MQ=255)
          ccTTCGCCGGCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGcc                                                                                                                                        <  4:311388/149‑1 (MQ=255)
           cTTCGCCGGCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCt                                                                                                                                       >  5:95228/1‑149 (MQ=255)
                 cGGCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCg                                                                                                                                 <  2:121615/149‑1 (MQ=255)
                  ggCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGa                                                                                                                                <  3:224367/149‑1 (MQ=255)
                   gCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGAc                                                                                                                               >  4:244204/1‑149 (MQ=255)
                        gCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAggg                                                                                                                          >  7:275474/1‑149 (MQ=255)
                                aGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATc                                                                                                                   >  4:352427/1‑148 (MQ=255)
                                     ttttCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGCAGATATCCAGGc                                                                                                              >  1:128452/1‑148 (MQ=255)
                                          cGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATc                                                                                                          >  6:2574/1‑147 (MQ=255)
                                           gCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAg                                                                                                       >  6:75976/1‑149 (MQ=255)
                                           gCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGGAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTGGGTCGCCCCGGGCGATATCCAGGCCATCGAg                                                                                                       >  3:273532/1‑149 (MQ=255)
                                             cAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGc                                                                                                     <  8:275474/149‑1 (MQ=255)
                                                     cACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCg                                                                                             >  2:359978/1‑149 (MQ=255)
                                                       cGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTg                                                                                                   <  1:136326/141‑1 (MQ=255)
                                                       cGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTg                                                                                                   >  2:136326/1‑141 (MQ=255)
                                                        gggCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGCTTGAACTGCTCGc                                                                                                                                         >  7:57340/1‑102 (MQ=255)
                                                        gggCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGCTTGAACTGCTCGc                                                                                                                                         >  7:173751/1‑102 (MQ=255)
                                                        gggCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGCTTGAACTGCTCGc                                                                                                                                         <  8:173751/102‑1 (MQ=255)
                                                        gggCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGCTTGAACTGCTCGc                                                                                                                                         <  8:57340/102‑1 (MQ=255)
                                                          gCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAgg                                                                                                      >  7:274578/1‑135 (MQ=255)
                                                          gCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAgg                                                                                                      <  8:274578/135‑1 (MQ=255)
                                                              tctcGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAggg                                                                                                                          <  6:337471/111‑1 (MQ=255)
                                                              tctcGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAggg                                                                                                                          >  5:337471/1‑111 (MQ=255)
                                                                tcGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATcc                                                                                                                  <  2:223992/117‑1 (MQ=255)
                                                                tcGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATcc                                                                                                                  >  1:223992/1‑117 (MQ=255)
                                                                  gTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCAccc                                                                                   <  3:244204/146‑1 (MQ=255)
                                                                   tCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCAccccc                                                                                 >  8:59542/1‑147 (MQ=255)
                                                                        gCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTaga                                                                          <  3:352427/149‑1 (MQ=255)
                                                                        gCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTa                                                                            >  4:330759/1‑147 (MQ=255)
                                                                        gCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTa                                                                            >  4:325445/1‑147 (MQ=255)
                                                                          cGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAgc                                                                        <  7:59542/149‑1 (MQ=255)
                                                                                  cacaGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCg                                                                                                                                          >  2:303837/1‑75 (MQ=255)
                                                                                  cacaGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATgg                                                                 <  6:70213/148‑1 (MQ=255)
                                                                                  cacaGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGc                                                                >  4:358111/1‑149 (MQ=255)
                                                                                       ggCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAgc                                                           >  6:13930/1‑149 (MQ=255)
                                                                                             cagGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGt                                                     <  2:124167/149‑1 (MQ=255)
                                                                                              agGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGtt                                                    >  1:26350/1‑149 (MQ=255)
                                                                                                  ccTGGCTCAGGTCCGGGGGCAGGGGCAGGTAGTGGGTGGCGAGCAGTTCCAGCTGCTCGCCTTGGTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCt                                                <  4:273532/149‑1 (MQ=255)
                                                                                                    tGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGc                                              >  5:260977/1‑149 (MQ=255)
                                                                                                      gcgcAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGa                                            <  3:330759/149‑1 (MQ=255)
                                                                                                      gcgcAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGa                                            <  3:325445/149‑1 (MQ=255)
                                                                                                       cgcAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAg                                           >  3:96674/1‑149 (MQ=255)
                                                                                                                     cATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGcc                                 <  1:333933/145‑1 (MQ=255)
                                                                                                                     cATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGcc                                 >  2:333933/1‑145 (MQ=255)
                                                                                                                      aTGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTc                            >  5:87076/1‑149 (MQ=255)
                                                                                                                          gCAGGTAGTGGGTGGCGAGCAGTTCTAGCTGGTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCAGGGCTTAGCGGTTGTTCGCTGCGAGCAGGGTGGCGTTTTCCTGa                        <  8:287266/149‑1 (MQ=255)
                                                                                                                           cAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGAt                       >  6:82839/1‑149 (MQ=255)
                                                                                                                             ggTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATcc                     <  5:2574/149‑1 (MQ=255)
                                                                                                                                 gtgggtggCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATAc                 <  1:359978/149‑1 (MQ=255)
                                                                                                                                  aacaaggCGAGCAGCTTGAACTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATACg                >  7:68164/6‑149 (MQ=255)
                                                                                                                                    ggtggCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATACggg              <  5:82839/149‑1 (MQ=255)
                                                                                                                                          gAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATACGGGCAAt          >  7:23396/1‑147 (MQ=255)
                                                                                                                                             cAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATACGGGCAATCAGCg     <  3:358111/149‑1 (MQ=255)
                                                                                                                                                ttCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATACGGGCAATCAGCggct  <  8:23396/149‑1 (MQ=255)
                                                                                                                                                  |                                                                                                                                                  
TTGGCGGATACCTTCGCCGGCCAGGCTGGCCCAGCGGTTTTCCGCCAGTGCTGCACGGGCAATCTCGTCAGGGCCGCTGCTGCACAGGGCCAGCAGGTCCTGGCGCAGGTCCGGGGGCATGGGCAGGTAGTGGGTGGCGAGCAGTTCAAGCTGCTCGCCTTGTTCGACCAGGGCGATATCCAGGCCATCGAGGCTGGTGCCGGACATCACCCCCAAGTAGAGCGCCATGGCTTAGCGCTTGTTCGCTGCGAGCAGGGTGGCCTTTTCCTGATCCATACGGGCAATCAGCGGCT  >  NC_002947/521068‑521360

Alignment Legend
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 14 ≤ ATCG/ATCG < 27 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 36 ≤ ATCG/ATCG
Unaligned base: atcg    Masked matching base: atcg    Alignment gap:     Deleted base: