| Predicted mutation | |||||||
|---|---|---|---|---|---|---|---|
| evidence | seq id | position | mutation | freq | annotation | gene | description |
| RA | NC_002947 | 980,752 | T→G | 6.9% | L64R (CTG→CGG) | hscB → | DnaJ‑like molecular chaperone |
| Read alignment evidence... | |||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| seq id | position | ref | new | freq | score (cons/poly) | reads | annotation | genes | product | ||
| * | NC_002947 | 980,752 | 0 | T | G | 6.9% | 161.0 / 4.5 | 58 | L64R (CTG→CGG) | hscB | DnaJ‑like molecular chaperone |
| Reads supporting (aligned to +/- strand): ref base T (34/20); new base G (2/2); total (36/22) | |||||||||||
| Fisher's exact test for biased strand distribution p-value = 6.30e-01 | |||||||||||
| Kolmogorov-Smirnov test that lower quality scores support variant p-value = 4.37e-01 | |||||||||||
GCTTCCGTCTGGATCTCGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGATGAAGCCGA > NC_002947/980605‑980896 | gCTTCCGTCTGGATCTCGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTgc > 1:696718/1‑150 (MQ=255) gTCTGGATCTCGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGAGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTg > 1:475775/1‑150 (MQ=255) gATCTCGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGcgccg > 2:574364/1‑150 (MQ=255) tctcGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCcgcg > 2:580601/1‑150 (MQ=255) tcGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTc > 1:818991/1‑150 (MQ=255) tcGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTc < 1:645679/150‑1 (MQ=255) tcGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCGGCGCACTGCGCAGCGTc < 2:589621/150‑1 (MQ=255) tcGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCGGCGCACTGCGCAGCGTc > 1:589621/1‑150 (MQ=255) gACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCGGCGCACTGCGCAGCGTctg < 2:292995/150‑3 (MQ=255) aCAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTcgcg > 1:66113/1‑150 (MQ=255) cAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTcgcgc > 2:336176/1‑150 (MQ=255) aaGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTcgcgcg > 1:383583/1‑150 (MQ=255) cTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCgcgcgcgc > 1:456078/1‑150 (MQ=255) aCTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACctg > 2:68613/1‑150 (MQ=255) gCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGCCGCTTACCCGACGCTGCGCCGTGCGCCGCGTCGCGCGCGCTACCTGCTgg < 1:574364/150‑1 (MQ=255) gCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTgg < 1:402353/150‑1 (MQ=255) tATCGCGAGCTGGCCCTCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGcc > 2:336591/1‑150 (MQ=255) tATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGcc > 2:959435/1‑150 (MQ=255) tATCGCGAGCTGGCCCCCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGTGCGCTACCAGCTGGcc > 2:569554/1‑150 (MQ=255) aTCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCa < 2:818991/150‑1 (MQ=255) gcgAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCa < 2:456078/150‑1 (MQ=255) gCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCAc < 1:580601/150‑1 (MQ=255) cgcgAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGACCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGaa < 1:336176/150‑1 (MQ=255) cgAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGt < 1:56451/150‑1 (MQ=255) tCCATCCTGATCGCTTTGCCTACGCCTCCGAGCGTGAGCAGCGTATTGCGATGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGcccc > 2:80443/1‑150 (MQ=255) tCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGcccc > 1:666483/1‑150 (MQ=255) aTCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCagg > 1:105717/1‑150 (MQ=255) aTCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCagg > 1:364064/1‑150 (MQ=255) tGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGt > 2:856781/1‑150 (MQ=255) aTCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCa > 1:811961/1‑150 (MQ=255) tCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCAc > 1:592383/1‑150 (MQ=255) cGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACg < 1:517299/150‑1 (MQ=255) tttGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTc > 1:917911/1‑150 (MQ=255) gCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCAc < 2:917911/150‑1 (MQ=255) gCCTCCGTGCGTGAGCTGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCt < 2:570062/150‑1 (MQ=255) gAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTc < 2:666483/150‑1 (MQ=255) gTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCctgc < 2:364064/150‑1 (MQ=255) gcGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTgcagca > 2:394239/1‑150 (MQ=255) cGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGcancag < 2:696718/150‑1 (MQ=255) cgcTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGt < 2:475775/150‑1 (MQ=255) tGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGc > 1:906783/1‑150 (MQ=255) gAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGTTCCGTACTATAGATCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGt < 1:569554/150‑1 (MQ=255) aaaaaTCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTg > 1:174021/1‑150 (MQ=255) aaaTCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGACACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGaa > 1:516144/1‑150 (MQ=255) gCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCgaa < 2:2472/150‑1 (MQ=255) aaCGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTg > 2:833456/1‑150 (MQ=255) aaCGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCGCGAAGACCTg > 1:116538/1‑150 (MQ=255) cgacgCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCa > 1:456018/1‑150 (MQ=255) gacgCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAg > 2:662180/1‑150 (MQ=255) acgCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAgg < 2:66113/150‑1 (MQ=255) acgCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAgg < 2:620474/150‑1 (MQ=255) gCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGa < 2:139240/149‑1 (MQ=255) gCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGa > 1:139240/1‑149 (MQ=255) ttACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGATGa > 1:556747/1‑150 (MQ=255) cAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGATGAAGcc > 2:6232/1‑150 (MQ=255) cAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGATGAAGcc > 1:813931/1‑150 (MQ=255) cAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGATGAAGcc > 2:903693/1‑150 (MQ=255) gACGCGGCGCACTGCGCAGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGATGAAGCCGa > 2:897991/1‑150 (MQ=255) | GCTTCCGTCTGGATCTCGACAAGCTGGCCACTCGCTATCGCGAGCTGGCCCGCGAAGTCCATCCTGATCGCTTTGCCGACGCCTCCGAGCGTGAGCAGCGTATTGCGCTGGAAAAATCCGCGGCCCTCAACGACGCTTACCAGACGCTGCGCAGTGCGCCGCGTCGCGCGCGCTACCTGCTGGCCATCAGCGGCCACGAAGTGCCCCAGGAGGTCACGGTCCACGACCCTGACTTCCTGCTGCAGCAGATGCAGTGGCGTGAAGAGCTCGAAGAACTGCAGGATGAAGCCGA > NC_002947/980605‑980896 |
| Alignment Legend |
|---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 22 ≤ ATCG/ATCG < 32 ≤ ATCG/ATCG < 41 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |