New junction evidence | |||||||||||
---|---|---|---|---|---|---|---|---|---|---|---|
seq id | position | reads (cov) | reads (cov) | score | skew | freq | annotation | gene | product | ||
* | ? | NC_000913_3_hsa_tpiA | = 938046 | 63 (1.050) | 4 (0.070) | 4/264 | 8.4 | 6.5% | coding (53/1344 nt) | rarA | recombination intermediate processing DNA‑dependent ATPase |
? | NC_000913_3_hsa_tpiA | = 938052 | 57 (1.010) | coding (59/1344 nt) | rarA | recombination intermediate processing DNA‑dependent ATPase | |||||
Rejected: Coverage evenness skew score above cutoff. | |||||||||||
Rejected: Frequency below/above cutoff threshold. |
GCAAAATGGGGCTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTACCGGCAAAACAACTCTCGCTGAA > NC_000913_3_hsa_tpiA/937905‑938197 | gCAAAATGGGGCTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGC‑CTATGAAGTTGCAGGTCTTAGGGTAATACGATTCAACCTCTGGCCGCGCGTATg > 1:777793/1‑149 (MQ=255) aaTGGGGCTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGGTCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGc > 1:1027032/1‑149 (MQ=255) aTGGGGCTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGcc < 1:183204/149‑1 (MQ=255) tGGGGCTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCa < 2:865723/149‑1 (MQ=255) cTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGaaaa < 2:687931/149‑1 (MQ=255) cTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGaaaa > 1:687931/1‑149 (MQ=255) tgGATGCAGCGAAATTTACCTTCACTCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATTCGGCCAGAAAAttt > 2:14344/1‑149 (MQ=255) ggATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTa < 1:874882/149‑1 (MQ=255) ggATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTa < 2:600088/149‑1 (MQ=255) tGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGca < 2:33006/149‑1 (MQ=255) cAGCAAAATTTACCTCGACCCCGACGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGcaca < 1:910056/149‑1 (MQ=255) gCGAAATTTACCTTCACCCCGCCGCAAGGCGGCACGGTAGATGATCAACGTAAGCAGAGGCACCTGAGTGAGCAAGCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGt < 2:115782/149‑1 (MQ=255) tttCCCTGCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATCATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCg < 1:228296/149‑1 (MQ=255) tttACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTGGCACAGTATATCg > 1:430706/1‑149 (MQ=255) ttCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGGCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCCCAGTATTACGGCCCGc > 2:682367/1‑149 (MQ=255) tCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCa > 1:273213/1‑149 (MQ=255) aCCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAAc > 2:23107/1‑149 (MQ=255) cccGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAAcca > 1:125577/1‑147 (MQ=255) cccGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACAt > 1:1028586/1‑149 (MQ=255) ggccgcAAGGCGGCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCTATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACAttt < 1:463666/148‑1 (MQ=255) cgccgcAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACAttt < 2:986726/149‑1 (MQ=255) ccgcAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTgc < 2:273213/149‑1 (MQ=255) cgcAAGGCGTCACGGTAGATGCTAAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTCTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTgct < 1:976071/149‑1 (MQ=255) gTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCgg < 2:345976/149‑1 (MQ=255) gTAGATGATCAACGGAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGc < 2:55110/149‑1 (MQ=255) aGATGAGCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCg < 1:802416/149‑1 (MQ=255) tgatCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTg < 2:647854/149‑1 (MQ=255) gatCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAg > 2:299153/1‑101 (MQ=255) gatCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAg < 1:299153/101‑1 (MQ=255) gatCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACa > 1:242019/1‑123 (MQ=255) gatCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACa < 2:242019/123‑1 (MQ=255) cGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCcgcgcg > 2:739226/1‑149 (MQ=255) aaGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTa < 1:546621/149‑1 (MQ=255) aGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTAt < 1:956201/149‑1 (MQ=255) ggCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAAAATTTGCTGGCTGCGGGGAAGCCGGTGCCGCGCGCTATCGAAGc > 1:264441/1‑149 (MQ=255) aCCTGAGTGAGCCATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGATGGTGATCCGTTGCCGCGCGCTATCGAAGCCgg < 1:792833/149‑1 (MQ=255) tgagtgagCAATATGTCGTT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCa < 1:138883/149‑1 (MQ=255) gagtgagCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTgctg > 2:103075/1‑107 (MQ=255) gagtgagCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTgctg < 1:103075/107‑1 (MQ=255) tgagCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACCTTTGCGGGGTGCGGGGGAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTa > 1:143592/1‑149 (MQ=255) gagCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGTAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTAc > 1:890876/1‑149 (MQ=255) gagCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTAc > 1:515604/1‑149 (MQ=255) agCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTAcg > 2:776706/1‑148 (MQ=255) gCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACAt > 2:435057/1‑149 (MQ=255) gCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCACTATCGAAGCCGGGCATTTCCAt > 2:435068/1‑149 (MQ=255) cAATCTGTCGCC‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACAtt < 2:671910/149‑1 (MQ=255) aaTCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTc < 1:1024646/149‑1 (MQ=255) tCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTa < 1:1002684/149‑1 (MQ=255) tGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAACATTTAGCCCAGTAGATCGGCCAGCAACATTTGCTGGCTACGAGGAAGCCGTTGCGGCGCGCTATCTACGCCGGGCCTTTACACTCTaag > 2:724989/1‑147 (MQ=255) cT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGATAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCct > 1:698017/1‑149 (MQ=255) cT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTATCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATAGAAGCCGGGCATTTACATTCTATGATCct > 1:436376/1‑149 (MQ=255) cT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCct > 1:754136/1‑149 (MQ=255) gATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTg < 2:515604/149‑1 (MQ=255) tttttCGGATAATACTTTTCAGCCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTggg < 2:999919/149‑1 (MQ=255) ataataCTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGccgccg < 1:104456/149‑1 (MQ=255) ttCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTACCGGc > 1:363213/1‑149 (MQ=255) tttGGCCGCGCGTAGGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTACCGGCAAaacaa < 2:403940/147‑1 (MQ=255) cgcgcgTCTGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTAGCGGTAAAACAACTCTCg > 1:910029/1‑149 (MQ=255) ccggcgTATGCGGCGAGAAAATTTCGCACAGTACACCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTACCGGCAACACAACTGTCg < 2:455516/146‑1 (MQ=255) gcgggTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTACCGGCAAAACAACTCTCGc < 1:267485/149‑1 (MQ=255) gTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTACCGGCAAAACAACTCTCGCTGaa < 2:754136/149‑1 (MQ=255) | GCAAAATGGGGCTGTGGATGCAGCGAAATTTACCTTCACCCCGCCGCAAGGCGTCACGGTAGATGATCAACGTAAGTAGAGGCACCTGAGTGAGCAATCTGTCGCT‑CGATTTTTCGGATAATACTTTTCAACCTCTGGCCGCGCGTATGCGGCCAGAAAATTTAGCACAGTATATCGGCCAGCAACATTTGCTGGCTGCGGGGAAGCCGTTGCCGCGCGCTATCGAAGCCGGGCATTTACATTCTATGATCCTCTGGGGGCCGCCGGGTACCGGCAAAACAACTCTCGCTGAA > NC_000913_3_hsa_tpiA/937905‑938197 |
Alignment Legend |
---|
Aligned base mismatch/match (shaded by quality score): ATCG/ATCG < 3 ≤ ATCG/ATCG < 12 ≤ ATCG/ATCG < 22 ≤ ATCG/ATCG < 37 ≤ ATCG/ATCG < 41 ≤ ATCG/ATCG |
Unaligned base: atcg Masked matching base: atcg Alignment gap: ‑ Deleted base: ‑ |
Reads not counted as support for junction |
read_name Not counted due to insufficient overlap past the breakpoint. |
read_name Not counted due to not crossing MOB target site duplication. |