breseq  version 0.35.4  revision f352f80f4bc9
mutation predictions | marginal predictions | summary statistics | genome diff | command line log

Predicted mutations
evidence position mutation annotation gene description
RA 31,923 T→C G369G (GGT→GGC carB → carbamoyl phosphate synthetase subunit beta
RA 89,416 A→G intergenic (+384/‑218) cra → / → mraZ DNA‑binding transcriptional dual regulator Cra/DNA‑binding transcriptional repressor MraZ
RA 114,650 C→T A359T (GCG→ACG)  hofC ← inner membrane protein HofC
RA 124,133 G→A A373T (GCA→ACA)  aceE → pyruvate dehydrogenase E1 component
RA 160,636 C→T intergenic (‑32/+146) dksA ← / ← sfsA RNA polymerase‑binding transcription factor DksA/putative DNA‑binding transcriptional regulator of maltose metabolism
RA 178,882 A→G V91A (GTC→GCC)  mtn ← 5'‑methylthioadenosine/S‑adenosylhomocysteine nucleosidase
RA 184,069 A→G G9G (GGT→GGC yaeH ← DUF3461 domain‑containing protein YaeH
RA 213,556 T→C V409A (GTA→GCA)  tilS → tRNA(Ile)‑lysidine synthetase
MC JC 257,908 Δ776 bp insB9[crl] insB9, insA9, [crl]
RA 268,692 T→A D90V (GAT→GTT)  ykfA ← CP4‑6 prophage; putative GTP‑binding protein YkfA
RA 293,744 T→C S59G (AGC→GGC)  yagL ← CP4‑6 prophage; resolvase‑like catalytic domain‑containing protein YagL
RA 333,891 C→T P181P (CCG→CCA yahB ← putative LysR‑type DNA‑binding transcriptional regulator YahB
RA 342,291 T→C R389R (CGT→CGC yahJ → putative deaminase with metallo‑dependent hydrolase domain
RA 392,964 T→A intergenic (‑63/‑6) insE‑2 ← / → yaiT IS3 element protein InsE/putative autotransporter YaiT
RA 418,653 A→G G255G (GGA→GGG phoR → sensory histidine kinase PhoR
RA 493,290 C→T A400V (GCA→GTA) 
A400V (GCA→GTA) 
dnaX →
dnaX →
DNA polymerase III subunit tau
DNA polymerase III subunit tau
RA 494,207 G→A V44V (GTG→GTA ybaB → putative nucleoid‑associated protein YbaB
RA 527,577 T→C intergenic (+36/‑4) rhsD → / → ybbC protein RhsD/PF15631 family protein YbbC
RA 527,915 (A)5→4 coding (335/369 nt) ybbC → PF15631 family protein YbbC
RA 589,810 A→G L382P (CTG→CCG)  nfrA ← bacteriophage N4 receptor, outer membrane protein
RA 596,062 G→A E155K (GAG→AAG)  cusC → copper/silver export system outer membrane channel
RA 626,292 A→G T75A (ACC→GCC)  entE → 2,3‑dihydroxybenzoate‑AMP ligase
RA 684,378 C→T G12D (GGT→GAT)  rihA ← pyrimidine‑specific ribonucleoside hydrolase RihA
RA 735,136 (G)6→7 pseudogene (917/1434 nt) ybfO → conserved protein, rhs‑like YbfO
RA 742,127 A→G Y144H (TAT→CAT)  dtpD ← dipeptide:H(+) symporter DtpD
RA 746,576 (G)5→6 coding (642/792 nt) nei → endonuclease VIII
RA 810,745 A→G K122R (AAA→AGA)  bioF → 8‑amino‑7‑oxononanoate synthase
RA 868,422 (C)8→7 coding (903/1872 nt) gsiA → glutathione ABC transporter ATP binding subunit GsiA
RA 889,923 A→G intergenic (‑104/‑166) ybjL ← / → ybjM putative transport protein YbjL/putative inner membrane protein
RA 892,129 T→C L55L (TTA→CTA)  rimK → ribosomal protein S6 modification protein
RA 911,763 G→A R130C (CGT→TGT)  hcr ← NADH oxidoreductase
RA 916,431 A→G intergenic (‑384/‑42) aqpZ ← / → ybjD water channel AqpZ/DUF2813 domain‑containing protein YbjD
RA 932,340 (A)8→7 intergenic (‑290/‑255) trxB ← / → lrp thioredoxin reductase/DNA‑binding transcriptional dual regulator Lrp
RA 947,956 C→T A243V (GCG→GTG)  ycaM → putative transporter YcaM
RA 960,601 T→C V113A (GTT→GCT)  ycaL → periplasmic protease YcaL
RA 989,500 T→C D286G (GAC→GGC)  pncB ← nicotinate phosphoribosyltransferase
RA 994,316 T→A I173F (ATC→TTC)  ssuC ← aliphatic sulfonate ABC transporter membrane subunit
RA 1,010,898 C→T A312V (GCC→GTC)  uup → ATP‑binding protein with possible role in replication
RA 1,033,499 A→G V82V (GTA→GTG hyaB → hydrogenase 1 large subunit
RA 1,048,196 C→T A166T (GCA→ACA)  gfcC ← capsule biosynthesis GfcC family protein
RA 1,051,785 T→C C34C (TGT→TGC ymcF → protein YmcF
RA 1,143,140 T→C T410A (ACT→GCT)  rne ← ribonuclease E
RA 1,157,016 A→G L80L (TTA→TTG ycfH → putative metal‑dependent hydrolase YcfH
RA 1,162,230 C→T H116Y (CAT→TAT)  hinT → purine nucleoside phosphoramidase
RA 1,167,058 G→A G325D (GGC→GAC)  ndh → NADH:quinone oxidoreductase II
RA 1,200,928 A→G C35C (TGT→TGC xisE ← e14 prophage; putative excisionase
RA 1,220,971 G→A pseudogene (1371/2648 nt) ycgH → putative transporter component, N‑terminal fragment
RA 1,245,222 T→C S21S (AGT→AGC ycgY → uncharacterized protein YcgY
RA 1,260,031 A→G V258A (GTG→GCG)  dauA ← aerobic C4‑dicarboxylate transporter DauA
RA 1,289,178 A→G intergenic (‑46/‑67) ychJ ← / → rssA NTF2‑like domain‑containing protein YchJ/putative patatin‑like phospholipase RssA
RA 1,318,571 (C)6→7 coding (1218/1362 nt) trpC ← fused indole‑3‑glycerol phosphate synthase/phosphoribosylanthranilate isomerase
RA 1,330,165 A→G E278E (GAA→GAG sohB → S49 peptidase family protein
RA 1,351,196 (G)7→6 intergenic (‑157/+211) fabI ← / ← ycjD enoyl‑[acyl‑carrier‑protein] reductase/DUF559 domain‑containing protein YcjD
RA 1,375,151 C→T F63F (TTC→TTT ycjQ → putative zinc‑binding dehydrogenase YcjQ
RA 1,428,424 A→G D101D (GAT→GAC insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,428,432 G→A L99L (CTG→TTG)  insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,428,451 T→C R92R (CGA→CGG insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,428,463 G→A R88R (CGC→CGT insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,428,652 G→C L25M (CTC→TTG insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,428,654 G→A L25M (CTC→TTG)  insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,428,669 G→T R20R (CGA→AGA)  insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,428,686 G→C T14S (ACT→AGT)  insH‑5 ← Rac prophage; IS5 transposase and trans‑activator
RA 1,453,034 A→G V203V (GTT→GTC paaZ ← oxepin‑CoA hydrolase/3‑oxo‑5,6‑dehydrosuberyl‑CoA semialdehyde dehydrogenase
RA 1,475,119 (T)7→6 intergenic (+38/‑25) pdxI → / → ydbD pyridoxine 4‑dehydrogenase/DUF2773 domain‑containing protein YdbD
RA 1,517,056 A→G intergenic (+54/+43) patD → / ← yncL gamma‑aminobutyraldehyde dehydrogenase/uncharacterized protein YncL
RA 1,541,351 C→T E414K (GAA→AAA)  narZ ← nitrate reductase Z subunit alpha
RA 1,594,132 (C)8→7 pseudogene (3955/5422 nt) yneO ← AIDA‑I family autotransporter YneO
RA 1,597,640 C→T pseudogene (447/5422 nt) yneO ← AIDA‑I family autotransporter YneO
RA 1,604,757 T→C R237R (CGT→CGC lsrD → Autoinducer‑2 ABC transporter membrane subunit LsrD
RA 1,634,642 C→T G82S (GGC→AGC)  tfaQ ← Qin prophage; putative tail fiber assembly protein TfaQ
RA 1,656,072 G→A A89T (GCC→ACC)  ynfB → DUF1283 domain‑containing protein YnfB
RA 1,663,395 G→A G136R (GGG→AGG)  ynfG → putative oxidoreductase YnfG
RA 1,673,673 T→C intergenic (‑172/‑240) mdtJ ← / → tqsA multidrug/spermidine efflux pump membrane subunit MdtJ/autoinducer 2 exporter
RA 1,685,542 (C)6→5 coding (1047/1404 nt) fumC ← fumarase C
RA 1,688,868 T→C V98A (GTT→GCT)  manA → mannose‑6‑phosphate isomerase
RA 1,695,427 T→C E215E (GAA→GAG uidA ← beta‑glucuronidase
RA 1,710,630 A→G T143A (ACC→GCC)  rsxG → SoxR [2Fe‑2S] reducing system protein RsxG
RA 1,715,617 T→C E91E (GAA→GAG pdxY ← pyridoxal kinase 2
RA 1,728,437 G→A A31T (GCC→ACC)  rnt → RNase T
RA 1,749,625 T→C T242A (ACC→GCC)  ydhU ← putative cytochrome YdhU
RA 1,781,438 T→C V15A (GTT→GCT)  ydiS → putative oxidoreductase with FAD/NAD(P)‑binding domain
RA 1,794,760 T→C I131M (ATA→ATG btuC ← vitamin B12 ABC transporter membrane subunit
RA 1,843,273 T→C G301G (GGT→GGC gdhA → glutamate dehydrogenase
RA 1,844,210 T→C D221G (GAC→GGC)  ynjI ← DUF1266 domain‑containing protein YnjI
RA 1,873,384 A→G K448K (AAA→AAG dgcJ → putative diguanylate cyclase DgcJ
JC JC 1,879,829 Δ1 bp :: IS186 (–) +6 bp :: Δ1 bp coding (115‑120/360 nt) yeaR ← DUF1971 domain‑containing protein YeaR
RA 1,881,626 T→C T62A (ACC→GCC)  dmlR ← DNA‑binding transcriptional regulator DmlR
RA 1,922,460 T→C E170E (GAA→GAG pphA ← phosphoprotein phosphatase 1
RA 1,970,991 T→C intergenic (‑7/+39) tap ← / ← tar methyl‑accepting chemotaxis protein Tap/methyl‑accepting chemotaxis protein Tar
RA 1,972,741 (G)6→7 intergenic (‑50/+95) tar ← / ← cheW methyl‑accepting chemotaxis protein Tar/chemotaxis protein CheW
MC JC 1,978,503 Δ776 bp insB‑5insA‑5 insB‑5, insA‑5
RA 2,018,260 (A)8→7 coding (315/444 nt) fliJ → flagellar biosynthesis protein FliJ
RA 2,061,601 T→C L111L (TTA→TTG nac ← DNA‑binding transcriptional dual regulator Nac
RA 2,072,889 A→G T451A (ACC→GCC)  flu → CP4‑44 prophage; self recognizing antigen 43 (Ag43) autotransporter
RA 2,077,174 (G)5→6 coding (63/369 nt) cbeA → CP4‑44 prophage; cytoskeleton bundling‑enhancing antitoxin CbeA
RA 2,081,543 A→G G335G (GGT→GGC dacD ← D‑alanyl‑D‑alanine carboxypeptidase DacD
RA 2,117,670 T→C A245A (GCA→GCG wcaK ← putative colanic acid biosynthesis pyruvyl transferase
RA 2,147,047 T→C D165G (GAC→GGC)  alkA ← DNA‑3‑methyladenine glycosylase 2
RA 2,173,363 Δ2 bp pseudogene (915‑916/1358 nt) gatC ← galactitol‑specific PTS enzyme IIC component
RA 2,183,628 (T)7→8 coding (24/819 nt) yegX ← putative hydrolase
RA 2,232,517 G→A G225D (GGC→GAC)  cdd → cytidine/deoxycytidine deaminase
RA 2,254,047 G→A G33G (GGC→GGT nupX ← putative nucleoside transporter
RA 2,288,561 (C)7→8 pseudogene (354/2525 nt) yejO ← adhesin‑like autotransporter YejO
RA 2,290,778 C→T S93S (AGC→AGT narP → DNA‑binding transcriptional dual regulator NarP
MC 2,304,678 Δ282 bp between other eco → / ← mqo serine protease inhibitor ecotin/malate:quinone oxidoreductase
RA 2,446,579 T→C T299A (ACC→GCC)  aroC ← chorismate synthase
RA 2,449,457 T→C K198R (AAG→AGG)  yfcO ← DUF2544 domain‑containing protein YfcO
RA 2,462,889 (C)9→8 intergenic (+243/‑123) fadL → / → yfdF long‑chain fatty acid outer membrane channel/bacteriophage T2 receptor/protein YfdF
RA 2,494,781 T→C G28G (GGT→GGC ypdI → colanic acid synthesis putative lipoprotein YpdI
RA 2,527,823 T→C V293A (GTG→GCG)  yfeH → putative solute:Na(+) symporter
RA 2,590,374 T→C V927A (GTG→GCG)  acrD → multidrug efflux pump RND permease AcrD
RA 2,602,233 T→C V139A (GTG→GCG)  hyfB → hydrogenase 4 component B
RA 2,603,102 G→A G429S (GGT→AGT)  hyfB → hydrogenase 4 component B
RA 2,682,157 (C)7→6 coding (589/3282 nt) yphG ← DUF5107 domain‑containing protein YphG
RA 2,699,351 C→T A198V (GCG→GTG)  yfhH → putative DNA‑binding transcriptional regulator YfhH
RA 2,706,770 C→T A119T (GCC→ACC)  lepA ← elongation factor 4
RA 2,715,149 T→C T58A (ACC→GCC)  yfiE ← putative LysR‑type DNA‑binding transcriptional regulator YfiE
RA 2,745,554 T→C Y122C (TAC→TGC)  rimM ← ribosome maturation factor RimM
RA 2,768,673 T→C R3R (CGT→CGC yfjQ → CP4‑57 prophage; protein YfjQ
RA 2,769,648 (C)6→7 intergenic (+162/‑55) yfjQ → / → yfjR CP4‑57 prophage; protein YfjQ/CP4‑57 prophage; putative DNA‑binding transcriptional regulator
RA 2,809,415 T→C pseudogene (1100/1178 nt) ygaY → putative transporter YgaY, N‑terminal fragment
RA 2,811,134 A→G H122R (CAC→CGC)  mprA → DNA‑binding transcriptional repressor MprA
RA 2,839,566 G→A A15T (GCA→ACA)  ascF → beta‑glucoside specific PTS enzyme IIBC component
MC JC 2,857,096 Δ2,538 bp coding (4‑2541/2562 nt) mutS → DNA mismatch repair protein MutS
RA 2,862,411 T→C L26P (CTA→CCA)  ygbK → putative 3‑oxo‑tetronate kinase YgbK
RA 2,865,178 A→G V26V (GTA→GTG ygbN → putative transporter YgbN
RA 2,949,993 (T)5→6 coding (752/1332 nt) argA → N‑acetylglutamate synthase
RA 2,970,592 T→C V58A (GTT→GCT)  ygdQ → UPF0053 inner membrane protein YgdQ
RA 2,972,909 (C)6→7 coding (954/1194 nt) lplT ← lysophospholipid transporter
RA 2,977,063 T→C C155C (TGT→TGC galR → DNA‑binding transcriptional dual regulator GalR
RA 2,984,896 G→A P233S (CCT→TCT)  yqeF ← putative acyltransferase
RA 2,986,581 A→G V245V (GTA→GTG yqeG → putative transporter YqeG
RA 2,999,680 (G)7→8 coding (212/756 nt) ygeR ← LysM domain‑containing putative peptidase lipoprotein YgeR
RA 3,011,789 T→C V110A (GTT→GCT)  yqeA → putative amino acid kinase YqeA
RA 3,068,157 T→C intergenic (‑77/+16) yggE ← / ← argO uncharacterized protein YggE/L‑arginine exporter
RA 3,105,207 T→C F259L (TTC→CTC)  mltC → membrane‑bound lytic murein transglycosylase C
RA 3,230,215 T→C V443A (GTG→GCG)  ygjK → glycoside hydrolase
RA 3,267,951 T→C V33A (GTA→GCA)  yhaB → protein YhaB
RA 3,284,795 T→C C37C (TGT→TGC agaC → galactosamine‑specific PTS enzyme IIC component
RA 3,304,813 (C)7→6 coding (1005/1245 nt) mtr ← tryptophan:H(+) symporter Mtr
RA 3,354,487 C→T intergenic (‑437/‑238) yhcC ← / → gltB radical SAM family oxidoreductase YhcC/glutamate synthase subunit GltB
RA 3,388,726 A→G V134A (GTT→GCT)  aaeA ← aromatic carboxylic acid efflux pump membrane fusion protein
RA 3,436,053 C→T L283F (CTC→TTC)  rsmB → 16S rRNA m(5)C967 methyltransferase
RA 3,476,107 A→G S112P (TCC→CCC)  yheO ← putative DNA‑binding transcriptional regulator YheO
RA 3,526,366 T→C intergenic (‑217/‑103) nudE ← / → igaA ADP‑sugar diphosphatase NudE/inner membrane protein ‑ inhibits the Rcs signaling pathway
RA 3,546,188 T→C S189P (TCC→CCC)  nfuA → iron‑sulfur cluster carrier protein NfuA
RA 3,546,376 A→G intergenic (+177/‑183) nfuA → / → gntT iron‑sulfur cluster carrier protein NfuA/high‑affinity gluconate transporter
RA 3,551,116 +G coding (1358/2394 nt) malP ← maltodextrin phosphorylase
RA 3,560,455 +G pseudogene (151/758 nt) glpR ← DNA‑binding transcriptional repressor GlpR
RA 3,594,571 G→A L304L (CTG→TTG)  livM ← branched chain amino acid/phenylalanine ABC transporter membrane subunit LivM
RA 3,619,272 T→C R27R (CGT→CGC rhsB → rhs element protein RhsB
RA 3,627,990 G→A Q517* (CAG→TAG)  rbbA ← ribosome‑associated ATPase
RA 3,637,751 A→C N37T (AAC→ACC)  pitA → metal phosphate:H(+) symporter PitA
RA 3,707,324 C→T A128T (GCG→ACG)  dppA ← dipeptide ABC transporter periplasmic binding protein
RA 3,815,883 +C coding (667/687 nt) rph ← truncated RNase PH
RA 3,860,630 (C)5→4 coding (348/894 nt) yidL → putative DNA‑binding transcriptional regulator YidL
RA 3,861,098 A→G K272K (AAA→AAG yidL → putative DNA‑binding transcriptional regulator YidL
RA 3,868,448 G→A H288Y (CAT→TAT)  yidR ← DUF3748 domain‑containing galacturonate catabolism protein YidR
RA 3,906,596 (A)7→8 intergenic (‑29/+257) bglG ← / ← phoU transcriptional antiterminator BglG/negative regulator of the pho regulon
RA 3,948,805 (G)6→7 coding (1165/1521 nt) yifB ← putative magnesium chelatase YifB
RA 3,954,853 A→G D459G (GAC→GGC)  ilvD → dihydroxy‑acid dehydratase
RA 3,977,134 Δ1 bp coding (857/1251 nt) wzxE → lipid III flippase
RA 4,028,640 G→A L45L (CTG→TTG)  fadA ← 3‑ketoacyl‑CoA thiolase
RA 4,051,495 A→G N50S (AAC→AGC)  yihI → Der GTPase‑activating protein YihI
RA 4,084,255 Δ1 bp coding (1568/3051 nt) fdoG ← formate dehydrogenase O subunit alpha
RA 4,226,924 A→G T1033A (ACC→GCC)  metH → cobalamin‑dependent methionine synthase
RA 4,262,356 A→G K230E (AAG→GAG)  dusA → tRNA‑dihydrouridine synthase A
RA 4,277,869 A→G N134S (AAC→AGC)  soxR → DNA‑binding transcriptional dual regulator SoxR
RA 4,292,511 A→G I334V (ATC→GTC)  nrfE → putative cytochrome c‑type biogenesis protein NrfE
RA 4,296,381 +GC intergenic (+587/+55) gltP → / ← yjcO glutamate/aspartate : H(+) symporter GltP/Sel1 repeat‑containing protein YjcO
RA 4,304,978 A→G G540G (GGT→GGC yjcS ← alkyl sulfatase
RA 4,316,944 A→G V92A (GTA→GCA)  phnM ← RPnTP hydrolase
RA 4,335,825 C→T V403M (GTG→ATG)  adiC ← arginine:agmatine antiporter
RA 4,445,549 A→G T480A (ACC→GCC)  tamB → translocation and assembly module subunit TamB
RA 4,455,581 Δ1 bp coding (29/999 nt) fbp ← fructose‑1,6‑bisphosphatase 1
RA 4,456,162 A→G E126E (GAA→GAG mpl → UDP‑N‑acetylmuramate‑‑L‑alanyl‑gamma‑D‑glutamyl‑ meso‑2,6‑diaminoheptanedioate ligase
RA 4,460,176 A→G R63R (CGT→CGC nrdG ← anaerobic ribonucleoside‑triphosphate reductase activating protein
RA 4,506,416 C→T intergenic (+11/‑32) yjhC → / → ythA KpLE2 phage‑like element; putative oxidoreductase YjhC/KpLE2 phage‑like element; uncharacterized protein YthA
RA 4,511,128 A→G R110R (CGT→CGC fecE ← ferric citrate ABC transporter ATP binding subunit
RA 4,596,841 C→T S284S (AGC→AGT lgoD → L‑galactonate oxidoreductase
RA 4,606,215 (G)8→9 noncoding (72/87 nt) leuP ← tRNA‑Leu
RA 4,606,330 (G)8→9 noncoding (72/87 nt) leuQ ← tRNA‑Leu

Unassigned missing coverage evidence
   seq id start end size ←reads reads→ gene description
* * ÷ NC_000913 1427841 1428032–1427972 132–192 17 [10] [15] 18 insH‑5 Rac prophage; IS5 transposase and trans‑activator
* * ÷ NC_000913 1428196–1428294 1428417–1428392 99–222 16 [15] [14] 18 insH‑5 Rac prophage; IS5 transposase and trans‑activator
* * ÷ NC_000913 3423755–3424234 3424533–3424239 6–779 18 [15] [14] 16 [rrfD]–[rrlD] [rrfD],[rrlD]
* * ÷ NC_000913 4171671–4171751 4171953–4171786 36–283 16 [15] [13] 17 [rrfB] [rrfB]

Unassigned new junction evidence
  seq id position reads (cov) reads (cov) score skew freq annotation gene product
* ? NC_000913 = 12994980 (0.000)56 (1.020) 44/266 0.2 100% intergenic (+253/‑33) ychE/insH21 putative inner membrane protein/IS5 transposase and trans‑activator
?NC_000913 1300698 = 0 (0.000)intergenic (+151/‑484) insH21/oppA IS5 transposase and trans‑activator/oligopeptide ABC transporter periplasmic binding protein
* ? NC_000913 3363001 =65 (1.150)89 (1.590) 58/272 0.0 73.1% coding (195/2382 nt) yhcD putative fimbrial usher protein YhcD
?NC_000913 3766087 = 1 (0.020)coding (3905/4134 nt) rhsA rhs element protein RhsA
* ? NC_000913 = 3653230NA (NA)38 (0.670) 30/274 0.8 86.4% noncoding (1/1195 nt) IS5 repeat region
?NC_000913 = 3766089 6 (0.110)coding (3907/4134 nt) rhsA rhs element protein RhsA
* ? NC_000913 = 454269033 (0.580)18 (0.340) 13/256 2.6 38.8% intergenic (+57/‑425) fimE/fimA regulator for fimA/type 1 fimbriae major subunit
?NC_000913 = 4542986 26 (0.490)intergenic (+353/‑129) fimE/fimA regulator for fimA/type 1 fimbriae major subunit